106053-26-3Relevant academic research and scientific papers
Microwave-assisted, aqueous wittig reactions: Organic-solvent- And protecting-group-free chemoselective synthesis of functionalized alkenes
McNulty, James,Das, Priyabrata,McLeod, David
supporting information; experimental part, p. 6756 - 6760 (2010/08/06)
(Chemical Equation Presented) Free from protection! A general, chemoselective, protecting-group- and organic-solvent-free route to stilbenes and heterostilbenes involving the direct synthesis of triethyl benzylic and allylic phosphonium salts from the corresponding alcohols and their microwave-assisted, aqueous Wittig reactions is described.
Wittig-type olefination of alcohols promoted by nickel nanoparticles: Synthesis of polymethoxylated and polyhydroxylated stilbenes
Alonso, Francisco,Riente, Paola,Yus, Miguel
supporting information; experimental part, p. 6034 - 6042 (2010/02/28)
Nickel nanoparticles were found to promote the Wittig-type olefination of primary alcohols with phosphorus ylides. The latter can be prepared from the corresponding phosphonium salts with TiBuLi or in situ generated with lithium metal. The methodology is especially efficient for the synthesis of stilbenes and is applied in the absence of any additive as a hydrogen acceptor. A new approach, to the synthesis of polymethoxylated and polyhydroxylated stilbenes, including resveratrol, DMU-212 and analogues, is presented.
Synthesis and biological evaluation of some enantiomerically pure C8cC15 monoseco analogues of the phenanthroquinolizidine-type alkaloids cryptopleurine and julandine
Sydnes, Magne O.,Bezos, Anna,Burns, Christopher,Kruszelnicki, Irma,Parish, Christopher R.,Su, Stephen,Rae, A. David,Willis, Anthony C.,Banwell, Martin G.
, p. 506 - 520 (2008/12/20)
A series of enantiomerically pure C8cC15 monoseco analogues, 2330, of the alkaloids cryptopleurine (1) and julandine (2) have been prepared using cinnamyl chloride 37 and (S)- or (R)-2-methylpiperidine as key building blocks. Two related compounds, 31 and
Quinone reductase induction activity of methoxylated analogues of resveratrol
Zhang,Go
, p. 841 - 850 (2008/02/12)
Agents that induce the activity of phase II enzymes play an important role in intervening with the carcinogenic process at the initiation stage. Resveratrol is well known for its chemopreventive activity against major stages of carcinogenesis. In this study, several methoxylated analogues of resveratrol were synthesized and evaluated for their ability to induce the activity of the phase II enzyme quinone reductase (QR). Methoxy groups serve to increase lipophilicity and improve metabolic stability. Compared to resveratrol, analogues with ortho-methoxy substituents were found to be more potent inducers of QR and to exert their activity in a qualitatively different manner. The greater induction activities associated with these stilbenoids serve as a useful starting point for the design of improved chemopreventive agents.
Stilbene derivatives as anticancer agents
-
, (2008/06/13)
The present invention relates to stilbene derivatives which possess utility as anti-cancer agents. The compounds can be used to treat cancers which are susceptible to treatment therewith, and can be utilized in a method of treating such cancers. Pharmaceu
Synthesis and Evaluation of Analogues of (Z)-1-(4-Methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as Potential Cytotoxic and Antimitotic Agents
Cushman, Mark,Nagatarathnam, Dhanapalan,Gopal, D.,He, Hu-Ming,Lin, Chii M.,Hamel, Ernest
, p. 2293 - 2306 (2007/10/02)
A series of stilbenes has been prepared and tested for cytotoxicity in the five human cancer cell lines A-549 non-small cell lung, MCF-7 breast, HT-29 colon, SKMEL-5 melanoma, and MLM melanoma.The cis stilbenes 6a-f proved to be cytotoxic in all five cell
Syntheses og Stilbenes with a C2-Sidechain in o-Position and of their Deuteriated Analogues
Mayer, Klaus K.,Prior, Silvia,Wiegrebe, Wolfgang
, p. 511 - 532 (2007/10/02)
Syntheses of o-(β-aminoethyl)-stilbene-urethanes (types 1, 2 and 3) and o-(β-phenethyl)-stilbenes 4 are described.The urethanes are obtained by degradation of 1-benzyl-1,2,3,4-tetrahydroisoquinolines with ethylchloroformate; 4 is synthesized by reduction of desoxybenzoines, followed by o-formylation and Wittig-reaction.The deuteriated isotopomers were obtained via the corresponding deuteriated precursors. - Keywords: Stilbenes, o-substituted; Deuteriated compounds
