106063-36-9Relevant academic research and scientific papers
Reactivity of Quinone Imine and Quinone Diimine Metabolites of the Antitumor Drug Amsacrine and Related Compounds to Nucleophiles
Lee, Ho H.,Palmer, Brian D.,Denny, William A.
, p. 6042 - 6047 (2007/10/02)
The quinone diimine AQDI (7) and the quinone imine AQI (10) (products of oxidative metabolism of the clinical antileukemia drug amsacrine (1)) and related compounds were prepared, and their reactions with a variety of nucleophiles were studied.Reaction of
Redox Chemistry of the 9-Anilinoacridine Class of Antitumor Agents
Jurlina, Jeffrey L.,Lindsay, Andrew,Packer, John E.,Baguley, Bruce C.,Denny, William A.
, p. 473 - 480 (2007/10/02)
9-Anilinoacridines bearing a 1'-NHR substituent on the anilino ring undergo facile, chemically reversible, two-electron oxidation to quinone diimines.The chemical and electrochemical oxidation of three groups of 9-anilinoacridines (1'-substituted derivati
