1060715-15-2Relevant academic research and scientific papers
Synthesis of novel pyrazolo[5,1-b] [1,3]benzothiazoles: A new pericyclic pathway
Tekiner-Gulbas, Betuel,Filak, Laszlo,Vasko, Gyoengyver Agnes,Egyed, Orsolya,Yalcin, Ismail,Aki-Sener, Esin,Riedl, Zsuzsanna,Hajos, Gyoergy
experimental part, p. 2005 - 2012 (2009/04/06)
2-Benzylbenzothiazoles were easily N-aminated by tosyl hydroxylamine, and the obtained N-amino salts were reacted with ethyl orthoformate to give new derivatives of the pyrazolo[5,1-b][1,3]benzothiazole ring system. Mechanistic considerations suggest that the ring closure reaction proceeds via deprotonation of the N-amino salt followed by electrocyclization to provide the tricyclic ring system. The procedure opens an easy access to variously substituted derivatives of the target ring system.
