1060716-77-9Relevant academic research and scientific papers
Synthesis and conformational studies of a hybrid cyclic peptide based on cis-β-furanoid sugar amino acid (FSAA) and ornithine
Chandrasekhar, Srivari,Saritha, Birudaraju,Naresh, Police,Udayakiran, Marelli,Reddy, Chada Raji,Jagadeesh, Bharatam
experimental part, p. 1267 - 1276 (2009/02/07)
The conformational control of a 14-helix nucleating template, cis-β-furanoid sugar amino acid (FSAA), over a flexible δ-amino acid, ornithine is studied in a FSAA-ornithine cyclic tetrapeptide. Extensive NMR and MD studies reveal that the cyclic peptide adopts a three-dimentional bowl-shape cavity, which promotes six- and seven-membered intra- and inter-residue H-bonding, in polar and nonpolar solvents, respectively.
