1060801-23-1

Basic information

• Product Name: 1-(6-aminopyridin-2-yl)ethanone
• Synonyms: 1-(6-aminopyridin-2-yl)ethanone
• CAS NO: 1060801-23-1
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.15122
• Mol File: 1060801-23-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 295.1±20.0 °C(Predicted)
• Appearance: /
• Density: 1.168±0.06 g/cm3(Predicted)
• PKA: 2.78±0.10(Predicted)
• CAS DataBase Reference: 1-(6-aminopyridin-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-aminopyridin-2-yl)ethanone(1060801-23-1)
• EPA Substance Registry System: 1-(6-aminopyridin-2-yl)ethanone(1060801-23-1)

Safety Data

• Hazardous Substances Data: 1060801-23-1(Hazardous Substances Data)

Usage

Physical state

Yellow crystalline solid

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Structural features

Contains a pyridine ring
Amino group attached to the 6-position of the pyridine ring
Ketone group attached to the ethyl side chain

Potential applications

Development of new drugs
Building block for the synthesis of complex organic molecules

Industry relevance

Valuable chemical for research and development in the pharmaceutical and agricultural industries

Relevant articles and documents

Preparation method of 5-HT1F agonist compound

The invention relates to a preparation method of a 5-HT1F agonist compound. The preparation method of the 5-HT1F agonist compound comprises the steps that 2,3-butanedione and 2-halogenated acrylonitrile are subjected to 1,4-addition reaction to obtain 2-halogenated-5,6-dioxo n-heptanoic nitrile, then the 2-halogenated-5,6-dioxo n-heptanoic nitrile and ammonia are subjected to pyridine cyclizationand amino protection to obtain 2-disubstituted methylamino-6-acetyl pyridine, then 2-disubstituted methylamino-6-(1-methyl piperidine-4-base)formyl group piperidine is prepared through hydroxyethylation, sulfonic acid esterification and methylamine condensation reaction, and then the 5-HT1F agonist compound Lasmiditan is obtained through deprotection reaction and 2,4,6-trifluoro-benzoyl chloride amidation. The raw materials of the preparation method of the 5-HT1F agonist compound are easy to get, ultralow temperature reaction is avoided, the operation is simple and convenient, the cost is low,and industrial production of Lasmiditan is easy.