1060801-42-4

Basic information

• Product Name: (6-Chloro-pyridin-2-yl)-diMethyl-aMine
• Synonyms: (6-Chloro-pyridin-2-yl)-diMethyl-aMine
• CAS NO: 1060801-42-4
• Molecular Formula: C7H9ClN2
• Molecular Weight: 156.61276
• EINECS: -0
• Mol File: 1060801-42-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 252.5±20.0 °C(Predicted)
• Appearance: /
• Density: 1.181±0.06 g/cm3(Predicted)
• PKA: 3.51±0.10(Predicted)
• CAS DataBase Reference: (6-Chloro-pyridin-2-yl)-diMethyl-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: (6-Chloro-pyridin-2-yl)-diMethyl-aMine(1060801-42-4)
• EPA Substance Registry System: (6-Chloro-pyridin-2-yl)-diMethyl-aMine(1060801-42-4)

Safety Data

• Hazardous Substances Data: 1060801-42-4(Hazardous Substances Data)

Usage

General Description

(6-Chloro-pyridin-2-yl)-diMethyl-aMine is a chemical compound with the molecular formula C7H10ClN. It is a derivative of pyridine and contains a chlorine atom at the 6-position and two methyl groups attached to the amine functional group. (6-Chloro-pyridin-2-yl)-diMethyl-aMine is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It can also be used as a building block in the production of various chemical products. The presence of the pyridine ring in this compound gives it specific reactivity and properties that make it valuable in a range of chemical processes.

Upstream product

• 20885-12-5 2-chloro-6-fluoropyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 2402-78-0 2,6-dichloropyridine 

Relevant articles and documents

Amination of Aromatic Halides and Exploration of the Reactivity Sequence of Aromatic Halides

A base-promoted amination of aromatic halides has been developed using a limited amount of dimethylformamide (DMF) or amine as an amino source. Various aryl halides, including F, Cl, Br, and I, have been successfully aminated in good to excellent yields. Although the amination of aromatic halides with amines or DMF is usually considered as an aromatic nucleophilic substitution (SNAr) process, and the reactivity of an aromatic halide is F > Cl > Br > I, the reactivity of aromatic halides in this system was found to be I > Br a‰ F > Cl. This protocol also showed a good regioselectivity for multihalogenated aromatics. This protocol is valuable for industrial application due to the simplicity of operation, the unrestricted availability of amino sources and aromatic halides, transition metal-free conditions, no requirement for solvent, and scalability.

HETEROARYLSULFONYL-SUBSTITUTED PYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER

There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3 and X have meanings provided in the description, which compounds are useful in the treatment of cancers.