1060815-67-9

Basic information

• Product Name: 6-Bromo-2-chloronicotinic acid
• Synonyms: 6-Bromo-2-chloronicotinic acid
• CAS NO: 1060815-67-9
• Molecular Formula: C6H3BrClNO2
• Molecular Weight: 236.45052
• Mol File: 1060815-67-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 361.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.917±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.77±0.28(Predicted)
• CAS DataBase Reference: 6-Bromo-2-chloronicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-2-chloronicotinic acid(1060815-67-9)
• EPA Substance Registry System: 6-Bromo-2-chloronicotinic acid(1060815-67-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1060815-67-9(Hazardous Substances Data)

Usage

Uses

6-Bromo-2-chloronicotinic Acid can be used in the preparation of aminopyridyl carboxylates from halopyridyl carboxylates via regioselective copper(I)-catalyzed Ullmann amination using sodium azide.

Upstream product

• 1452-94-4 ethyl 2-chloronicotinate 
• 164464-49-7 ethyl 2-chloronicotinate-N-oxide 
• 1214335-22-4 6-bromo-2-chloro-nicotinic acid ethyl ester 

Downstream Products

• 1125410-08-3 6-bromo-2-chloronicotinaldehyde 
• 1214335-22-4 6-bromo-2-chloro-nicotinic acid ethyl ester 

Relevant articles and documents

Synthesis method for 2-chloro-6-bromo-3-pyridylaldehyde

The invention relates to a synthesis method for 2-chloro-6-bromo-3-pyridylaldehyde and mainly aims at solving the technical problem that an effective synthesis method has not been found at present. The synthesis method comprises the following steps of oxidizing ethyl 2-chloronicotinate to obtain a compound 1; reacting the compound 1 with phosphorus oxide bromide in acetonitrile to generate a compound 2; reacting the compound 2 with diisobutyl aluminum hydride, reducing ester group into hydroxyl to generate a compound 3; and reacting the compound 3 with Dess-Martin periodinane and oxidizing the hydroxyl into an aldehyde group to generate a target compound 4. The 2-chloro-6-bromo-3-pyridylaldehyde is widely applied to the pharmaceutical industry as a medical intermediate.