1060815-86-2

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine is used as a key intermediate in the synthesis of various drug candidates for the development of novel therapeutic agents.
Used in Anticancer Applications:
In the field of oncology, 2,4-Dichloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine is used as a potential anticancer agent for its ability to inhibit the growth of certain cancer cells. Its promising results in preclinical studies have positioned it as a candidate for further research and development in cancer treatment.
Used in Medicinal Chemistry Research:
Due to its unique structure and properties, 2,4-Dichloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine is utilized in medicinal chemistry research to explore its potential applications in the treatment of various diseases. Its versatility allows for the design and synthesis of new compounds with improved pharmacological profiles.

InChI:InChI=1S/C7H5Cl2N3/c1-3-2-10-6-4(3)5(8)11-7(9)12-6/h2H,1H3,(H,10,11,12)

Upstream product

• 90213-66-4 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine 
• 900789-14-2 5-bromo-2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine 
• 74-88-4 methyl iodide 
• 67856-03-5 5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diol 

Downstream Products

• 1116240-03-9 2,4-dichloro-5-methyl-7-tosyl-pyrrolo[2,3-d]pyrimidine 
• 1239876-18-6 2-(3-(2-Chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acetonitrile 
• 1190399-88-2 C₃₁H₄₀N₆O₃S 
• 1190400-75-9 C₃₂H₄₂N₆O₃S 

Relevant academic research and scientific papers

Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents

Focal adhesion kinase (FAK) is a ubiquitous intracellular non-receptor tyrosine kinase, which is involved in multiple cellular functions, including cell adhesion, migration, invasion, survival, and angiogenesis. In this study, a series of 7H-pyrrolo[2,3-d

2,4-DISUBSTITUTED 7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND MEDICINAL USE THEREOF

The present invention relates to a 2,4-disubstituted 7H-pyrrolo[2,3-d]pyrimidine derivative, a preparation method and a medicinal use thereof. In particular, the present invention discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof. For the definition of each group in formula (I), see the description for details.

PROTEIN KINASE INHIBITORS

Compounds, particularly compounds having spleen tyrosine kinase (Syk) inhibition activity, having the following structure: or a pharmaceutically acceptable salt thereof, wherein R1 is structure (a), (b), (c) or (d): and Ra, Rb, Rc, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of the same, as well as pharmaceutical compositions containing the same, are also disclosed, as well as uses of the same to treat a condition or disorder mediated by a Syk and/or JAK kinase.