106086-15-1

Basic information

• Product Name: tert-butyl 4-(hydroxymethyl)-2-phenyl-1,3-thiazolidine-3-carboxylate
• CAS NO: 106086-15-1
• Molecular Formula: C₁₅H₂₁N₃O₃S
• Molecular Weight: 295.3971
• Mol File: 106086-15-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 438.8°C at 760 mmHg
• Flash Point: 219.2°C
• Density: 1.185g/cm³
• Vapor Pressure: 1.79E-08mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: tert-butyl 4-(hydroxymethyl)-2-phenyl-1,3-thiazolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(hydroxymethyl)-2-phenyl-1,3-thiazolidine-3-carboxylate(106086-15-1)
• EPA Substance Registry System: tert-butyl 4-(hydroxymethyl)-2-phenyl-1,3-thiazolidine-3-carboxylate(106086-15-1)

Safety Data

• Hazardous Substances Data: 106086-15-1(Hazardous Substances Data)

Upstream product

• 106086-10-6 (4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidine-4-carboxylic acid 
• 106086-12-8 N-Oxysuccinimide N'-tert-butyloxycarbonyl-2-phenylthiazolidine-4-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 196930-46-8 (4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid 

Relevant articles and documents

Synthesis and in vitro studies of thiazolidine-4-carboxylic acid hydrazones as potential antitubercular agents

A series of forty six 2-substituted aryl-thiazolidine-4-carboxylic acid hydrazones (6a-c, 7a-c, 8a-c, 9a-c series) have been synthesized and isolated in their pure isomeric form (2R, 4R and 2S, 4R). Purity and structures have been ascertained by chromatographic and, IR, NMR and mass spectral data analysis. Antitubercular activity screening of these synthesized compounds against Mycobacterium tuberculosis H37Rv (MTB) and multi-drug resistant Mycobacterium tuberculosis (MDR-TB) has resulted in identification of three active compounds (6a 11, 6a 13, 6a 15) with MIC 10 μM against MTB and MDR-TB. The compound 6a 11 (2R, 4R isomer) shows the highest potency with MIC 1.33 μM against MDR-TB. It is observed that the antitubercular activity of 2R isomer is four times more than the corresponding 2S isomer.