1061-64-9 Usage
General Description
The chemical (3a,5b,7a,12a)- 3,7,12,24-tetrahydroxy-cholestan-26-oic acid is a derivative of cholic acid, a primary bile acid produced in the liver. It is characterized by its four hydroxyl groups at positions 3, 7, 12, and 24 on the cholestane backbone, as well as a carboxylic acid group at position 26. (3a,5b,7a,12a)- 3,7,12,24-tetrahydroxy-cholestan-26-oic acid plays a crucial role in the digestion and absorption of dietary fats, as it helps to emulsify and solubilize lipid molecules in the intestines, aiding in their uptake by the body. Additionally, it can act as a signaling molecule, binding to specific receptors in the liver and intestines to regulate bile acid synthesis and metabolism. As a result, (3a,5b,7a,12a)- 3,7,12,24-tetrahydroxy-cholestan-26-oic acid is essential for maintaining proper lipid and cholesterol homeostasis in the body.
Check Digit Verification of cas no
The CAS Registry Mumber 1061-64-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,6 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1061-64:
(6*1)+(5*0)+(4*6)+(3*1)+(2*6)+(1*4)=49
49 % 10 = 9
So 1061-64-9 is a valid CAS Registry Number.
InChI:InChI=1/C27H46O6/c1-14(5-8-21(29)15(2)25(32)33)18-6-7-19-24-20(13-23(31)27(18,19)4)26(3)10-9-17(28)11-16(26)12-22(24)30/h14-24,28-31H,5-13H2,1-4H3,(H,32,33)/t14-,15?,16+,17-,18-,19+,20+,21?,22-,23+,24+,26+,27-/m1/s1
1061-64-9Relevant articles and documents
IMPROVED SYNTHESIS OF 3α,7α,12α,24ξ-TETRAHYDROXY-5β-CHOLESTAN-26-OIC ACID
Batta, A. K.,Tint, G. S.,Dayal, B.,Shefer, S.,Salen, G.
, p. 693 - 702 (1982)
This paper describes three simple and short methods for the conversion of cholic acid into cholylaldehyde with protected hydroxyl groups.The first method involves lithium aluminium hydride reduction of the tetrahydropyranyl ether of methyl cholate and oxidation of the resulting primary alcohol with pyridinium chlorochromate.The second method employs diborane for the reduction of the -COOH group to the -CH2OH group, while the third method involves the reduction of 3α,7α,12α-triformyloxy-5β-cholan-24-oic acid (as the acid chloride) directly into 3α,7α,12α-triformyloxy-5β-cholan-24-al with TMA-ferride (tetramethylammonium hydridoirontetracarbonyl).The aldehyde obtained by any of the above methods underwent smooth Reformatsky reaction with ethyl α-bromopropionate to yield 3α,7α,12α,24ξ-tetrahydroxy-5β-cholestan-26-oic acid.