1061198-20-6

Basic information

• Product Name: N-((S)-cyclopropyl-phenyl-methyl)-3-methylsulfinyl-2-phenyl-quinoline-4-carboxamide
• Synonyms: N-((S)-cyclopropyl-phenyl-methyl)-3-methylsulfinyl-2-phenyl-quinoline-4-carboxamide
• CAS NO: 1061198-20-6
• Molecular Weight: 440.566
• Mol File: 1061198-20-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-((S)-cyclopropyl-phenyl-methyl)-3-methylsulfinyl-2-phenyl-quinoline-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((S)-cyclopropyl-phenyl-methyl)-3-methylsulfinyl-2-phenyl-quinoline-4-carboxamide(1061198-20-6)
• EPA Substance Registry System: N-((S)-cyclopropyl-phenyl-methyl)-3-methylsulfinyl-2-phenyl-quinoline-4-carboxamide(1061198-20-6)

Safety Data

• Hazardous Substances Data: 1061198-20-6(Hazardous Substances Data)

Upstream product

• 844470-80-0 (S)-N-cyclopropyl-N-phenylmethylamine hydrochloride 
• 5398-93-6 2-methylthio-1-phenyl-ethanone 
• 91-56-5 indole-2,3-dione 
• 400079-66-5 3-methylthio-2-phenyl-quinoline-4-carboxylic acid 
• 1061198-17-1 N-((S)-cyclopropyl-phenyl-methyl)-3-methylsulfanyl-2-phenyl-quinoline-4-carboxamide 

Relevant articles and documents

Synthesis and SAR of sulfoxide substituted carboxyquinolines as NK3 receptor antagonists

The neurokinin-3 (NK3) receptor is regarded as a potential novel target for treating patients with schizophrenia. Herein we report the synthesis and SAR of a series of C3-alkylsulfoxide substituted quinolines as potent NK3 receptor antagonists. These compounds have excellent NK3 functional activity, good selectivity and drug-like properties. Several key compounds have good in vitro/in vivo DMPK characteristics, and are active in a gerbil locomotor activity model.