106137-28-4Relevant articles and documents
Synthesis and Pharmacological Evaluation of 5,6-exo-Epoxy-7-oxabicycloheptane Derivatives
Das, Jagabandhu,Vu, Truc,Harris, Don N.,Ogletree, Martin L.
, p. 930 - 935 (2007/10/02)
-7-hept-2-yl>-5-heptenoic acid (31) and -7--7-oxabicyclohept-2-yl>-5-heptenoic acid (37) were found to be selective TxA2 antagonists at the platelet and pulmonary thromboxane receptors.An efficient stereospecific synthesis of these compounds and a series of structural analogues is described.Compounds 31 and 37 both inhibited the bronchoconstriction induced by arachidonic acid in the anesthetized guinea pig.