1061377-71-6 Usage
Chemical classification
Urea derivative
Bioactive properties
Potential kinase inhibitor
Kinase inhibition
Inhibits certain kinases, such as Fms-like tyrosine kinase 3 (FLT3)
Implications
Treatment of leukemia and other malignancies
Additional potential applications
Anti-inflammatory and anti-fibrotic agent
Structural characteristics
Presence of a cyclohexyl group and a morpholine ring
Pharmaceutical applications
Unique properties due to structural characteristics
Research status
More research needed to understand therapeutic potential and safety profile
Check Digit Verification of cas no
The CAS Registry Mumber 1061377-71-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,1,3,7 and 7 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1061377-71:
(9*1)+(8*0)+(7*6)+(6*1)+(5*3)+(4*7)+(3*7)+(2*7)+(1*1)=136
136 % 10 = 6
So 1061377-71-6 is a valid CAS Registry Number.
1061377-71-6Relevant articles and documents
Unsymmetrical non-adamantyl N,N′-diaryl urea and amide inhibitors of soluble expoxide hydrolase
Anandan, Sampath-Kumar,Webb, Heather K.,Do, Zung N.,Gless, Richard D.
scheme or table, p. 4259 - 4263 (2010/04/26)
Incorporation of an adamantyl group in prototypical soluble expoxide hydrolase (sEH) inhibitors afforded improved enzyme potency. We explored replacement of the adamantyl group in unsymmetrical ureas and amides with substituted aryl rings to identify equipotent and metabolically stable sEH inhibitors. We found that aryl rings, especially those substituted in the para position with a strongly electron withdrawing substituent, afforded enzyme IC50 values comparable to the adamantyl compounds in an ether substituted, unsymmetrical N,N′-diaryl urea or amide scaffold.