106139-63-3Relevant academic research and scientific papers
Estradiol-16alpha-carboxylic acid esters as locally active estrogens
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, (2008/06/13)
The present invention relates to analogs of estradiol, which, in their most preferred embodiment, act as locally active estrogens without significant systemic action. A series of 16α-carboxylic acid substituted steroids and their esters is presented which
Estradiol-16alpha-carboxylic acid esters as locally active estrogens.
Labaree,Reynolds,Hochberg
, p. 1802 - 1814 (2007/10/03)
We attempted to design analogues of estradiol to act as locally active estrogens without significant systemic action. We synthesized a series of 16alpha-carboxylic acid substituted steroids and their esters and tested their action in several assays of est
A Short, Stereoselective Route to 16α-(Substituted-alkyl)estradiol Derivatives
Fevig, Thomas L.,Katzenellenbogen, John A.
, p. 247 - 251 (2007/10/02)
A variety of 16α-substituted 17β-estradiol derivatives can be prepared by a convenient two-step procedure: The lithium enolate of estrone 3-O-benzyl or 3-O-tert-butyldimethylsilyl ether undergoes clean, stereospecific alkylation with a variety of allylic,
