106147-57-3

Basic information

• Product Name: 1-(1H-imidazol-5-yl)-2,2-diphenylethanol
• CAS NO: 106147-57-3
• Molecular Formula: C₁₇H₁₆N₂O
• Molecular Weight: 264.3217
• Mol File: 106147-57-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 457.4°C at 760 mmHg
• Flash Point: 230.4°C
• Density: 1.22g/cm³
• Vapor Pressure: 3.69E-09mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 1-(1H-imidazol-5-yl)-2,2-diphenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1H-imidazol-5-yl)-2,2-diphenylethanol(106147-57-3)
• EPA Substance Registry System: 1-(1H-imidazol-5-yl)-2,2-diphenylethanol(106147-57-3)

Safety Data

• Hazardous Substances Data: 106147-57-3(Hazardous Substances Data)

Upstream product

• 881-42-5 diphenylmethyllithium 

Relevant articles and documents

Synthesis and structure-activity of 4(5)-(2,2-diphenylethyl)imidazoles as new α2-adrenoreceptor antagonists

4(5)-(2,2-diphenylethyl)imidazole 6a is described as being a potent (pK(i) = 8.16 for displacement of [3H] p-aminoclonidine) and selective (selectivity = -log (pK(i) α2 - pK(i) α1) = 81) α2-adrenoreceptor antagonist (pA2 = 8.73 versus clonidine in the electrically stimulated guinea pig ileum) with additional activity as a norepinephrine uptake inhibitor (IC50 = 0.3 μM). An investigation of the structure-activity relationships of compounds closely related to 6a has been carried out. This included substitution of the phenyl and imidazole rings and modification of the link between these two ring systems. The various synthetic routes used are described. The affinity and the selectivity of the compounds for the α2 site were determined by studying the displacement of [3H] p-aminoclonidine and [3H] WB-4101 from rat forebrain membranes. The efficacy of the compounds was defined by measuring the antagonism of the clonidine effect on the electrically stimulated guinea pig ileum.