106147-85-7

Basic information

• Product Name: 4-(Chloromethyl)-5-methyl-1-(triphenylmethyl)-1H-imidazole
• Synonyms: 4-(Chloromethyl)-5-methyl-1-(triphenylmethyl)-1H-imidazole;4-(chloroMethyl)-5-Methyl-1-trityl-1H-iMidazole
• CAS NO: 106147-85-7
• Molecular Formula: C₂₄H₂₁ClN₂
• Molecular Weight: 372.89
• Mol File: 106147-85-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 133-135 °C
• Boiling Point: 517.571 °C at 760 mmHg
• Flash Point: 266.818 °C
• Appearance: /
• Density: 1.11
• PKA: 5.70±0.70(Predicted)
• CAS DataBase Reference: 4-(Chloromethyl)-5-methyl-1-(triphenylmethyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Chloromethyl)-5-methyl-1-(triphenylmethyl)-1H-imidazole(106147-85-7)
• EPA Substance Registry System: 4-(Chloromethyl)-5-methyl-1-(triphenylmethyl)-1H-imidazole(106147-85-7)

Safety Data

• Hazardous Substances Data: 106147-85-7(Hazardous Substances Data)

Usage

General Description

4-(Chloromethyl)-5-methyl-1-(triphenylmethyl)-1H-imidazole is a chemical compound with a complex structure, typically used as a reagent in synthetic chemistry. Its molecular formula is C27H23ClN2 and it belongs to the class of organic compounds known as tritylimidazoles. This category of chemicals is characterized by a structure that contains an imidazole ring which bears a trityl group. Its physical and chemical properties, such as solubility and melting point, can vary widely depending upon the specific conditions and combinations with other substances. It is not naturally occurring and has to be synthesized in a lab. Details about its specific use, toxicity, and safety measures can depend on the context in which it is used.

Upstream product

• 29636-87-1 4⁽⁵⁾-methyl-5⁽⁴⁾-hydroxymethylimidazole 
• 76-83-5 trityl chloride 
• 106147-84-6 4-Hydroxymethyl-5-methyl-1-(triphenylmethyl)imidazole 

Downstream Products

• 143075-60-9 2-(5-Methyl-1-trityl-1H-imidazol-4-ylmethyl)-2H-benzo[c][2,6]naphthyridin-1-one 

Relevant articles and documents

Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I

A series of compounds based on the carboxyl-terminal CAAL sequence of PGGTase-I substrates was designed and synthesized. Using piperazin-2-one as a semi-rigid scaffold, we have introduced critical pharmacophores in a well-defined arrangement to mimic the CAAL sequence. High potency and exceptional selectivity were obtained for inhibition of PGGTase-I with structures such as 45 and 70. Potency of this series of GGTIs was dependent on the presence of an l-leucine residue with a free carboxyl terminus, as well as an S configuration of the 3-aryl group. The selectivity was significantly enhanced by 5-methyl substitution on the imidazole ring and fluorine substitution on the 3-aryl group. Modification of the 6-position of the piperazinone scaffold was found to be unfavorable. Compounds 44 and 69, the corresponding methyl esters of 45 and 70, were found to selectively block processing of Rap1A by PGGTase-I in whole cells with IC50 values of 0.4 M and 0.7 M respectively. The Royal Society of Chemistry 2006.

3,3-disubstituted-oxindole derivatives useful as anticancer agents

The present invention relates to compounds of formula 1 and to pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein n is 0 or 1 and R1, R2, R3, R4, and R5are as defined herein. The above compounds of formula 1 are useful in the treatment of hyperproliferative disorders, such as cancer, in mammals. The invention also relates to pharmaceutical compositions containing the compounds of formula 1, to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering the compounds of formula 1 to a mammal requiring such treatment, and to methods of preparing compounds of formula 1.

ALPHA2-BLOCKING DERIVATIVES OF IMIDAZOLE

A compound of the formula: STR1 wherein X 1, X 2, Y 1 and Y 2, whether or not identical are hydrogen, a halogen such as fluoro, chloro or bromo, linear or branched alkyl of 1 to 3 carbon atoms, linear or branched alkoxy of 1 to 3 carbon atoms, carboxy, alkoxy-carbonyl of 1 to 3 carbon atoms or phenyl;R 1 is hydrogen, methyl or phenyl;R 2 and R 3, which may or may not be identical, are hydrogen, hydroxyl, linear or branched alkyl of 1 to 6 carbon atoms, or linear or branched alkoxy group of 1 to 4 carbon atoms;R 1 and R 2 may together form a carbon-carbon double bond; andR 4 and R 5 whether or not identical, are hydrogen, linear or branched alkyl or 1 to 3 carbon atoms.The compounds are useful as blocking agents of α 2-adrenergic receptors.