1061602-02-5

Basic information

• Product Name: (1R,4R)-4-(4-(4-(4-fluorophenyl)-2-(2-hydroxyethylthio)-1H-imidazol-5-yl)pyridin-2-ylamino)cyclohexanol
• CAS NO: 1061602-02-5
• Molecular Weight: 428.531
• Mol File: 1061602-02-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R,4R)-4-(4-(4-(4-fluorophenyl)-2-(2-hydroxyethylthio)-1H-imidazol-5-yl)pyridin-2-ylamino)cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,4R)-4-(4-(4-(4-fluorophenyl)-2-(2-hydroxyethylthio)-1H-imidazol-5-yl)pyridin-2-ylamino)cyclohexanol(1061602-02-5)
• EPA Substance Registry System: (1R,4R)-4-(4-(4-(4-fluorophenyl)-2-(2-hydroxyethylthio)-1H-imidazol-5-yl)pyridin-2-ylamino)cyclohexanol(1061602-02-5)

Safety Data

• Hazardous Substances Data: 1061602-02-5(Hazardous Substances Data)

Upstream product

• 1061602-00-3 2-(4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio)ethanol 
• 27489-62-9 trans-4-hydroxycyclohexylamine 

Relevant articles and documents

Unexpected reaction of 2-alkylsulfanylimidazoles to imidazol-2-ones: Pyridinylimidazol-2-ones as novel potent P38α mitogen-activated protein kinase inhibitors

While optimizing the synthesis of 2-alkylsulfanyl-5-(2-aminopyridin-4-yl) imidazoles, we identified an unexpected reaction to pyridinylimidazol-2-ones. 2-Alkylsulfanylimidazoles, bearing a 2-hydroxyethyl or a 2,3-dihydroxypropyl moiety at the imidazole C2-S position, were converted by heating into imidazol-2-ones. These imidazol-2-ones were tested for their ability to inhibit p38α MAP kinase and LPS-stimulated TNF-α release in HWB. Introduction of an amino moiety at the pyridine C2 position led to compounds showing potent enzyme inhibitory activity with double-digit nanomolar IC 50 values (5a: IC50 = 23 nM).