1062079-30-4Relevant academic research and scientific papers
The synthesis and structure-activity relationship of pyridazinones as glucan synthase inhibitors
Ting, Pauline C.,Kuang, Rongze,Wu, Heping,Aslanian, Robert G.,Cao, Jianhua,Kim, David W.,Lee, Joe F.,Schwerdt, John,Zhou, Gang,Wainhaus, Samuel,Black, Todd A.,Cacciapuoti, Anthony,McNicholas, Paul M.,Xu, Yiming,Walker, Scott S.
, p. 1819 - 1822 (2011/05/05)
A structure-activity relationship study of the lead 5-[4-(benzylsulfonyl) piperazin-1-yl]-4-morpholino-2-phenyl-pyridazin-3(2H)-one 1 has resulted in the identification of 2-(3,5-difluorophenyl)-4-(3-fluorocyclopentyloxy)-5-[4- (isopropylsulfonyl)piperazin-1-yl]-pyridazin-3(2H)-one 11c as a β-1,3-glucan synthase inhibitor. Compound 11c exhibited significant efficacy in an in vivo mouse model of Candida glabrata infection.
PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS
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Page/Page column 103; 110, (2008/12/07)
In its many embodiments, the present invention provides -substituted pyridazinone compounds as glucan synthase inhibitors, methods of preparing such compounds, pharmaceutical including one or more of such compounds, methods of preparing pharmaceutical formulations including one or more such compounds or one or more such compounds along with other antifungal agents, and methods of treatment, prevention, inhibition, or amelioration of one or more fungal infections associated with glucan synthase using such compounds or pharmaceutical compositions.
