1062161-06-1

Basic information

• Product Name: N-(4-(4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)acetamide
• Synonyms: N-(4-(4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)acetamide
• CAS NO: 1062161-06-1
• Molecular Weight: 512.614
• Mol File: 1062161-06-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-(4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)acetamide(1062161-06-1)
• EPA Substance Registry System: N-(4-(4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)acetamide(1062161-06-1)

Safety Data

• Hazardous Substances Data: 1062161-06-1(Hazardous Substances Data)

Upstream product

• 1062175-24-9 6-chloro-4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidine 
• 101251-09-6 (4-acetylaminophenyl)boronic acid 

Relevant articles and documents

ATP-competitive inhibitors of the mammalian target of rapamycin: Design and synthesis of highly potent and selective pyrazolopyrimidines

The mammalian target of rapamycin (mTOR), a central regulator of growth, survival, and metabolism, is a validated target for cancer therapy. Rapamycin and its analogues, allosteric inhibitors of mTOR, only partially inhibit one mTOR protein complex. ATP-competitive, global inhibitors of mTOR that have the potential for enhanced anticancer efficacy are described. Structural features leading to potency and selectivity were identified and refined leading to compounds with in vivo efficacy in tumor xenograft models.