1062205-20-2Relevant academic research and scientific papers
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors
Venkatesan, Aranapakam M.,Dehnhardt, Christoph M.,Chen, Zecheng,Santos, Efren Delos,Dos Santos, Osvaldo,Bursavich, Matthew,Gilbert, Adam M.,Ellingboe, John W.,Ayral-Kaloustian, Semiramis,Khafizova, Gulnaz,Brooijmans, Natasja,Mallon, Robert,Hollander, Irwin,Feldberg, Larry,Lucas, Judy,Yu, Ker,Gibbons, Jay,Abraham, Robert,Mansour, Tarek S.
scheme or table, p. 653 - 656 (2010/07/05)
This article describes the syntheses and SAR of a series of imidazolopyrimidine derivatives, which are evaluated as inhibitors of PI3-Kinase (PI3 K) and mTOR. These compounds were found to be ATP competitive with good tumor cell growth inhibition, and suppression of pathway specific biomakers such as phosphorylation of Akt at T308.
IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS
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Page/Page column 34-35, (2008/12/08)
The present invention relates to Imidazolopyrimidine Analogs, methods of making Imidazolopyrimidine Analogs, compositions comprising an Imidazolopyrimidine Analog, and methods for treating or preventing a PI3K-related disorder comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog. The invention also relates to methods for treating or preventing mTOR-related disorders comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog.
