1062227-99-9Relevant academic research and scientific papers
Fluorescence imaging of intracellular cadmium using a dual-excitation ratiometric chemosensor
Taki, Masayasu,Desaki, Mika,Ojida, Akio,Iyoshi, Shohei,Hirayama, Tasuku,Hamachi, Itaru,Yamamoto, Yukio
, p. 12564 - 12565 (2008)
We described here a coumarin-based dual-excitation ratiometric probe for cadmium, CadMQ. This fluorescence sensor has high quantum yields of 0.59 and 0.70 in the metal-free and Cd2+-bound forms, respectively, and has a dissociation constant of 0.16 nM for Cd2+. CadMQ is cell permeable and locates within the acidic compartments of the cells. We further show that CadMQ is a useful tool to ratiometrically probe the change in the intracellular Cd2+ levels with the use of two excited wavelengths. Copyright
