MK6-83 is a TRPML channel activator that plays a crucial role in restoring endolysosomal trafficking and maintaining zinc homeostasis within the lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

1062271-24-2

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Basic information
1. Product Name: MK6-83
2. Synonyms: MK6-83;spudl 05344
3. CAS NO:1062271-24-2
4. Molecular Formula: C16H20N2O2S2
5. Molecular Weight: 336.4722
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 1062271-24-2.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: 502.6±60.0 °C(Predicted)
3. Flash Point: N/A
4. Appearance: /
5. Density: 1.311±0.06 g/cm3(Predicted)
6. Refractive Index: N/A
7. Storage Temp.: -20°C Freezer, Under inert atmosphere
8. Solubility: Chloroform (Slightly), DMSO (Slightly)
9. PKA: 8.56±0.50(Predicted)
10. CAS DataBase Reference: MK6-83(CAS DataBase Reference)
11. NIST Chemistry Reference: MK6-83(1062271-24-2)
12. EPA Substance Registry System: MK6-83(1062271-24-2)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 1062271-24-2(Hazardous Substances Data)

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1062271-24-2 Usage

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Used in Pharmaceutical Industry:
MK6-83 is used as a therapeutic agent for the treatment of mucolipidosis type IV (MLIV), a rare genetic disorder characterized by the accumulation of lipids and mucopolysaccharides within the lysosomes of cells. By activating TRPML channels, MK6-83 helps to improve endolysosomal trafficking and restore zinc homeostasis in MLIV mutant fibroblasts, potentially alleviating the symptoms and complications associated with the disease.

Check Digit Verification of cas no

The CAS Registry Mumber 1062271-24-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,2,2,7 and 1 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1062271-24:
(9*1)+(8*0)+(7*6)+(6*2)+(5*2)+(4*7)+(3*1)+(2*2)+(1*4)=112
112 % 10 = 2
So 1062271-24-2 is a valid CAS Registry Number.

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(Code)Product description
CAS number
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Sigma
(SML1509) MK6-83 ≥98% (HPLC)
1062271-24-2
SML1509-5MG
983.97CNY
Detail

Sigma
(SML1509) MK6-83 ≥98% (HPLC)
1062271-24-2
SML1509-25MG
3,970.98CNY
Detail

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