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1062292-60-7

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1062292-60-7 Usage

Description

4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one is a chemical compound with the molecular formula C15H9BrFNO, belonging to the class of phthalazine derivatives. It is a white to light yellow solid with a high melting point and is known for its potential biological activities. 4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one is used in various organic synthesis and pharmaceutical processes, particularly in medicinal chemistry for drug discovery and development. The presence of bromine and fluorine atoms in the benzyl group suggests its potential use as a substrate for further modification to create novel pharmaceutical compounds with desirable properties.

Uses

Used in Pharmaceutical Industry:
4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential biological activities. Its unique structure with bromine and fluorine atoms in the benzyl group allows for further modification to develop novel drugs with improved properties.
Used in Organic Synthesis:
4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one serves as a valuable building block in organic synthesis, enabling the creation of a wide range of chemical compounds with diverse applications. Its versatile structure allows for various chemical reactions, making it a useful component in the synthesis of complex organic molecules.
Used in Drug Discovery and Development:
In the field of drug discovery and development, 4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one is utilized as a starting material or a scaffold for the design and synthesis of new drug candidates. Its potential biological activities and structural features make it a promising candidate for the development of innovative therapeutic agents.
Used as a Substrate for Further Modification:
Due to the presence of bromine and fluorine atoms in the benzyl group, 4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one can be used as a substrate for further chemical modifications. This allows researchers to explore the synthesis of new pharmaceutical compounds with enhanced properties, such as improved potency, selectivity, or bioavailability.

Check Digit Verification of cas no

The CAS Registry Mumber 1062292-60-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,2,2,9 and 2 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1062292-60:
(9*1)+(8*0)+(7*6)+(6*2)+(5*2)+(4*9)+(3*2)+(2*6)+(1*0)=127
127 % 10 = 7
So 1062292-60-7 is a valid CAS Registry Number.

1062292-60-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4‐(3-bromo-4-fluorobenzyl)phthalazin‐1(2H)‐one

1.2 Other means of identification

Product number -
Other names 4-(3-bromo-4-fluoro-benzyl)-2H-phthalazin-1-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1062292-60-7 SDS

1062292-60-7Relevant articles and documents

Preparation method of olaparib key intermediate

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, (2021/03/31)

The invention provides a preparation method of an olaparib key intermediates 4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one (a compound shown as a formula IV) and 2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzoic acid (a compound shown as a formula V). Specifically, (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonic acid dimethyl ester is used as a raw material to be subjected to a Wittig-Horner reaction with 3-bromo-4-fluorobenzaldehyde to obtain a formula III, the formula III and hydrazine hydrate are subjected to cyclization to obtain a formula IV, and the formula IV is subjected toa reaction with n-butyllithium and carbon dioxide to obtain an olaparib intermediate V. The method is economical and environment-friendly, and the yield is greatly improved.

Olaparib refining method

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, (2018/10/11)

The invention discloses an olaparib refining method, which comprises: (1) dissolving an olaparib crude product in a mixed solvent of ethyl acetate and acetone, and controlling the temperature at 45-50DEG C until olaparib is completely dissolved; (2) adding active carbon, decolorizing, filtering, cooling the filtrate to a temperature of -10-0 DEG C, crystallizing, and growing the crystal; and (3)filtering, washing the filtered solid by using acetone, and carrying out vacuum drying to obtain the refined olaparib. With the refining method of the present invention, the purity of the obtained olaparib can reach more than 99.9%, the total impurity and the single impurity are respectively controlled within 0.1% and 0.05%, the quality of the product is remarkably improved, the refining process is easy to operate, and the refining method is suitable for industrial production.

Process for the Preparation of Olaparib and Intermediates Thereof

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Paragraph 0070; 0071; 0072; 0073, (2017/09/02)

The present invention provides processes for the preparation of intermediate compounds of formulas (4) and (5) useful in the preparation of Olaparib. (X is chloride, bromide or iodide)

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