1062468-10-3Relevant articles and documents
Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile
Chen, Jianyong,Collins, Gregory T.,Zhang, Jian,Yang, Chao-Yie,Levant, Beth,Woods, James,Wang, Shaomeng
supporting information; experimental part, p. 5905 - 5908 (2009/09/29)
A series of compounds structurally related to pramipexole were designed, synthesized, and evaluated as ligands for the dopamine 3 (D3) receptor. Compound 12 has a Ki value of 0.41 nM to D3 and a selectivity of > 30000- and 800-fold over the D1-like and D 2 receptors, respectively. Our in vivo functional assays showed that this compound is a partial agonist at the D3 receptor with no detectable activity at the D2 receptor.