1062575-48-7Relevant academic research and scientific papers
A samarium(II)-mediated, stereoselective cyclization for the synthesis of azaspirocycles
Guazzelli, Giuditta,Duffy, Lorna A.,Procter, David J.
supporting information; experimental part, p. 4291 - 4294 (2009/06/06)
(Chemical Equation Presented) Unsaturated keto-lactams undergo sequential conjugate reduction-aldol cyclization on treatment with SmI2 to give syn-spirocyclic pyrrolidinones and piperidinones containing vicinal, fully substituted stereocenters with complete diastereocontrol. The substituent on nitrogen and the lactam ring size have a marked impact on the efficiency of the spirocyclization.
