1062613-75-5

Upstream product

• 2362-12-1 4-Bromo-2-methylphenol 
• 888327-32-0 4-bromo-1-(difluoromethoxy)-2-methylbenzene 
• 1062613-73-3 ((4-(difluoromethoxy)-3-methylphenyl)ethynyl)trimethylsilane 

Downstream Products

• 1062613-78-8 1-(difluoromethoxy)-4-((4-fluorophenyl)ethynyl)-2-methylbenzene 
• 1062614-64-5 1-(difluoromethoxy)-4-((3-ethoxy-4-fluorophenyl)ethynyl)-2-methylbenzene 
• 1062614-72-5 2-(2,2-difluoroethoxy)-4-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-1-fluorobenzene 

Relevant academic research and scientific papers

AMYLOID PROTEIN-SELECTIVE BACE INHIBITORS (ASBIS) FOR ALZHEIMER'S DISEASE

The present disclosure provides various compounds, compositions, and methods of BACE inhibition that interact with both BACE and APP to increase selectivity of the inhibitor. Compounds presented herein exhibit desirably low IC50 values and permeability ac

AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5- PHENYLIMIDAZOLONE COMPOUNDS AS ?-SECRETASE INHIBITORS

The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula (I) The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.