1062682-69-2Relevant articles and documents
Electronic effects in the reaction of 1,3-diaryl-1,3-diketones with hydrazinopyridines
Duncan, Nathan C.,Garner, Charles M.,Nguyen, Tim,Hung, Fernando,Klausmeyer, Kevin
, p. 5766 - 5769 (2008/12/22)
The regioselectivity of the condensation of electronically unsymmetrical 1,3-diaryl-1,3-diketones with 2-hydrazinopyridine and 2,6-bis-hydrazinopyridine to form N-(2-pyridyl)-3,5-diarylpyrazoles was studied. Significant electronic effects on regioselectivities were observed, and regioselectivities were opposite to those exhibited by perfluoroalkyl/alkyl 1,3-diketones. The electronic effects correlate well to the difference between the Hammett σ+ coefficients of the para substituents on the aryl rings.
