106283-26-5

Basic information

• Product Name: Pt(C₆H₁₁NH₂)(NH₃)(CH₂(COO)2)
• CAS NO: 106283-26-5
• Molecular Weight: 413.333
• Mol File: 106283-26-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pt(C₆H₁₁NH₂)(NH₃)(CH₂(COO)2)(CAS DataBase Reference)
• NIST Chemistry Reference: Pt(C₆H₁₁NH₂)(NH₃)(CH₂(COO)2)(106283-26-5)
• EPA Substance Registry System: Pt(C₆H₁₁NH₂)(NH₃)(CH₂(COO)2)(106283-26-5)

Safety Data

• Hazardous Substances Data: 106283-26-5(Hazardous Substances Data)

Upstream product

• 146924-19-8 cis-Pt(NH₃)(cyclohexylamine)I₂ 
• 141-95-7 sodium malonate 

Relevant articles and documents

Synthesis, cytotoxicity, and DNA-binding levels of ammine/cyclohexylamine platinum(II) complexes with dicarboxylates

Four new ammine/cyclohexylamine platinum(II) complexes with dicarboxylates (a-d) have been synthesized and characterized by elemental analysis, conductivity, IR, UV, and 1HNMR spectra techniques. The cytotoxicity of the complexes was tested by MTT assay. The cell cycle analysis and the levels of total platinum bound to DNA were measured by flow cytometry and ICP-MS. The results show that the cytotoxicity of complexes (a-d) against EJ, HCT-8, BGC-823, HL-60, and MCF-7 cell lines decreases in the sequence: b > a > c > d. Complexes (a-d) have better cytotoxicity against EJ and HL-60 and complex (b) demonstrates cytotoxicity superior to that of the clinically established cisplatin. The complexes (a-d) induced a concentration-dependent accumulation of HL-60 cells in the G2/M phase of the cell cycle as cisplatin. The levels of total platinum bound to DNA in HL-60 and EJ cells decrease in the sequence: b > cisplatin > a > c > d under the same experimental conditions. Copyright