106308-41-2

Usage

Uses

Used in Pharmaceutical Industry:
Rufinamide Related Compound A (25 mg) (1-(2-Fluorobenzyl)-1H-1,2,3-triazole-4-carboxamide) is used as an impurity in the synthesis of Rufinamide for its anticonvulsant properties. It plays a role in the development and production of antiepileptic medications, specifically targeting sodium channels to reduce the frequency and severity of seizures in patients with epilepsy.
Additionally, as an impurity in the synthesis of Rufinamide, it may also be relevant in the quality control and regulatory aspects of drug manufacturing, ensuring the safety and efficacy of the final product.

Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF 1,2,3-TRIAZOLE-4 CARBOXAMIDES

The invention relates to the preparation of 1,2,3-triazole-4-carboxamide of general Formula I: wherein R1 and R2 may be the same or different and are selected from H, F, Cl, Br, I, OR, C(O)R, NH2, NHR or NR2. R can be a linear or branched alkyl group, for example a C1-C4 alkyl group. In exemplary embodiments, R1 and R2 are independently selected from H, F, Cl, Br, and I. The compound of Formula I can be Rufinamide.

Aralkyltriazole compounds

1-phenyl-lower alkyl-1H-1,2,3-triazole compounds of the formula STR1 in which Ph represents phenyl substituted by up to and including 3 substituents selected from lower alkyl, halogen and trifluoromethyl, alk represents lower alkylidene, and wherein either R1 represents hydrogen, lower alkyl, lower alkoxy, amino, N-lower alkylamino, N,N-di-lower alkylamino, N-lower alkanoylamino, carbamoyl, N-lower alkanoylcarbamoyl, N-lower alkylcarbamoyl or N,N-di-lower alkylcarbamoyl and R2 represents carbamoyl, N-lower alkanoylcarbamoyl, N-lower alkylcarbamoyl or N,N-di-lower alkylcarbamoyl or R1 represents carbamoyl, N-lower alkanoylcarbamoyl, N-lower alkylcarbamoyl or N,N-di-lower alkylcarbamoyl and R2 represents hydrogen or lower alkyl, have anti-convulsive properties and can be used as medicaments.