106359-70-0

Basic information

• Product Name: 4-(Naphthalen-2-yl)benzoic acid
• Synonyms: 4-(2-Naphthyl)benzoicacid; 4-(Naphthalen-2-yl)benzoic acid
• CAS NO: 106359-70-0
• Molecular Formula: C₁₇H₁₂O₂
• Molecular Weight: 248.28
• Mol File: 106359-70-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 451.4±24.0 °C(Predicted)
• Appearance: /
• Density: 1.232±0.06 g/cm3(Predicted)
• PKA: 4.19±0.10(Predicted)
• CAS DataBase Reference: 4-(Naphthalen-2-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Naphthalen-2-yl)benzoic acid(106359-70-0)
• EPA Substance Registry System: 4-(Naphthalen-2-yl)benzoic acid(106359-70-0)

Safety Data

• Hazardous Substances Data: 106359-70-0(Hazardous Substances Data)

Usage

General Description

4-(Naphthalen-2-yl)benzoic acid, also known as 2-naphthoylbenzoic acid, is a chemical compound with the molecular formula C18H12O2. It consists of a naphthalene group attached to a benzoic acid group, and is commonly used as a fluorescent probe for detecting structural changes in proteins. 4-(Naphthalen-2-yl)benzoic acid is also known for its potential use in organic electronic devices and as a precursor to various pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable molecule for research and industrial applications in various fields, including medicine, materials science, and chemistry.

Upstream product

• 205823-29-6 4-(2-naphthyl)benzoic acid methyl ester 
• 586-76-5 4-Bromobenzoic acid 
• 32316-92-0 naphthalene-2-boronic acid 
• 456-22-4 4-Fluorobenzoic acid 
• 1245607-84-4 2-naphthyltitanium triisopropoxide 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 619-58-9 4-iodobenzoic acid 
• 931120-45-5 4-naphthalen-2-yl-benzoic acid 2,4-bis-octadecyloxybenzyl ester 
• 619-44-3 methyl 4-iodobenzoate 
• 580-13-2 2-bromonaphthalene 

Downstream Products

• 106359-62-0 4-(2-naphthyl)phenyl hydroxamic acid 
• 1261633-97-9 C₁₇H₁₁ClO 
• 612-94-2 2-phenylnaphthalene 

Relevant articles and documents

A general palladium-catalyzed cross-coupling of aryl fluorides and organotitanium (IV) reagents

Pd(OAc)2/1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxy-piperidine was demonstrated to effectively catalyze cross-coupling of aryl fluoride and aryl(alkyl) titanium reagent. Both electron-deficient and electron-rich aryl fluoride can react effectively with nucleophile and provide extensive functional groups tolerance. 2-Arylated product was realized by selective activation of the C–F bond. Graphic abstract: [Figure not available: see fulltext.].

One-step highly selective borylation/Suzuki cross-coupling of two distinct aryl bromides in pure water

A Na2PdCl4-catalysed B2(OH)4-mediated direct cross-coupling of two distinct aryl bromides in pure water is described. This one-step borylation/Suzuki method exhibits an outstanding cross-coupling selectivity and no tendency to produce homocoupling products, therefore leading to biaryls and heterobiaryls in moderate to good yields. Moreover, the reaction has high regio-selectivity and can be scaled-up. Using such a simple, economical and practical protocol, the unsymmetrical diarylation of 3,5-dibromopryidine is achieved.

PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERSAS AS AGONISTS OF G- PROTEIN COUPLED RECEPTOR 43 (GPR43)

The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.