106366-30-7

Usage

Uses

Used in Recreational Applications:
2-(2-Phenylethyl)pyrrolidine is used as a recreational substance for its stimulant and euphoric effects, providing users with a temporary sense of heightened energy and mood enhancement.
Used in Scientific Research:
2-(2-Phenylethyl)pyrrolidine is used as a building block in the synthesis of other compounds, contributing to the development of new pharmaceuticals and chemical entities. Its unique chemical structure makes it an interesting target for study, with potential applications in various research areas.
Used in Psychopharmacology:
In the field of psychopharmacology, 2-(2-Phenylethyl)pyrrolidine is used as a research tool to understand the mechanisms of action of psychoactive substances. Its effects on the central nervous system provide insights into the development of new therapeutic agents for the treatment of various neurological and psychiatric disorders.

InChI:InChI=1/C12H17N/c1-2-5-11(6-3-1)8-9-12-7-4-10-13-12/h1-3,5-6,12-13H,4,7-10H2

Upstream product

• 106366-23-8 2-(1-phenylethyl)-3,4-dihydro-5H-pyrrole 
• 6628-68-8 ethyl 2-(ethoxycarbonyl)-4-phenylbutanoate 
• 103-63-9 1-phenyl-2-bromoethane 
• 346423-24-3 1-(1,3-dioxolan-2-yl)-5-phenylpentan-3-ol 
• 346423-31-2 2-(3-azido-5-phenylpentyl)-1,3-dioxolane 
• 1567842-73-2 C₂₅H₃₉N₃O₆ 
• 346423-32-3 1-(2-[1,3]dioxolan-2-yl-ethyl)-3-phenyl-propylamine 

Downstream Products

• 1567843-71-3 C₁₃H₁₉N₃*ClH 
• 1570523-35-1 C₁₃H₁₉N₃ 
• 613676-51-0 2-methyl-5-{[2-(2-phenylethyl)-1-pyrrolidinyl]carbonyl} pyridine 

Relevant academic research and scientific papers

DIRECT C-H AMINATION AND AZA-ANNULATION

In some aspects, the present disclosure provides methods of aminating an aromatic compound comprising reacting an aminating agent with an aromatic compound in the presence of a rhodium catalyst. In some embodiments, the methods may comprise aminating an aromatic compound which contains multiple different functional groups. The methods described herein may also be used to create bicyclic system comprising reacting an intramolecular aminating agent with an aromatic ring to obtain a second ring containing a nitrogen atom. In another aspect, the methods described herein may also be used to create a cyclic aliphatic cyclic/poly cyclic amine system comprising a reacting an intramolecular aminating agent by insertion into a C(sp3)-H bond.

Tf2O-Promoted Intramolecular Schmidt Reaction of the ω-Azido Carboxylic Acids

A designed Tf2O-promoted intramolecular Schmidt reaction of 2-substituted ω-azido carboxylic acids was demonstrated. Tf2O was used as an activation reagent for the carboxylic acid, and ω-azido anhydride was in situ generated, releasing a molecular TfOH, which acted as an acid promoter for the Schmidt process. A series of 2-substituted pyrrolidines was produced and acetylated for better purification. The strategy was also efficient for conversion of a 4-substituted ω-azido carboxylic acid to the tricyclic lactam.

The insulin secretory action of novel polycyclic guanidines: Discovery through open innovation phenotypic screening, and exploration of structure-activity relationships

We report the discovery of the glucose-dependent insulin secretogogue activity of a novel class of polycyclic guanidines through phenotypic screening as part of the Lilly Open Innovation Drug Discovery platform. Three compounds from the University of California, Irvine, 1-3, having the 3- arylhexahydropyrrolo[1,2-c]pyrimidin-1-amine scaffold acted as insulin secretagogues under high, but not low, glucose conditions. Exploration of the structure-activity relationship around the scaffold demonstrated the key role of the guanidine moiety, as well as the importance of two lipophilic regions, and led to the identification of 9h, which stimulated insulin secretion in isolated rat pancreatic islets in a glucose-dependent manner.

MODULATORS OF CENTRAL NERVOUS SYSTEM NEUROTRANSMITTERS

Disclosed are agents having pharmacological activity against cellular receptors and intracellular singaling, particularly receptors and sigaling pathways of central nervous system (CNS) neurotransmitters. Also disclosed are related methods and compositions for the treatment or prevention of diseases or disorders using the agents.

THE PREPARATION OF "ELONGATED" NICOTINE ANALOGUES

The preparation of four nicotine analogues having one or two additional methylene units between the N-methylpyrrolidinyl moiety and the aromatic ring are reported.Also prepared are the corresponding nornicotine and myosmine analogues.The course of the Spa