106367-16-2

Upstream product

• 2579-22-8 Phenylpropargyl aldehyde 
• 298229-64-8 1‐(thiophen‐2‐yl)ethanone oxime acetate 
• 100749-30-2 2-Methanesulfinyl-1-phenyl-5-thiophen-2-yl-pentane-1,5-dione 

Relevant academic research and scientific papers

Cu-Catalyzed Cascade Cyclization of Ketoxime Acetates and Alkynals Enabling Synthesis of Acylpyrroles

A facile copper-based catalytic system has been developed to enable efficient cyclization of methylketoximes and alkynals. This protocol provides a viable entry to synthetically and pharmaceutically useful 2-acylpyrroles with a broad range of compatible functionalities. Mechanistically, a key acyl migration is probably involved that leads to the formation of N-acyl pyrroles or otherwise NH pyrroles by further hydrolysis. More importantly, the present reaction system also gives an opportunity to realize three-component pyrrole assembly by simple addition of carboxylic acid.

Eine bequeme Synthese von 2-Aroyl-5-arylpyrrolen

2-Aroyl-5-arylpyrroles are prepared in 20-60percent yields by cyclocondensation of 1,5-diaryl-2-methylsulfinyl-1,5-pentanediones with ammonium acetate in acetic acid.