1063734-49-5

Basic information

• Product Name: 1-Methyl-1H-pyrazol-4-aMine dihydrochloride
• Synonyms: 1-Methyl-1H-pyrazol-4-aMine dihydrochloride;1-Methylpyrazol-4-amine,dihydrochloride;1-METHYL-1H-PYRAZOL-4-AMINE 2HCL
• CAS NO: 1063734-49-5
• Molecular Formula: C4H9Cl2N3
• Molecular Weight: 170.04036
• Mol File: 1063734-49-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1-Methyl-1H-pyrazol-4-aMine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-pyrazol-4-aMine dihydrochloride(1063734-49-5)
• EPA Substance Registry System: 1-Methyl-1H-pyrazol-4-aMine dihydrochloride(1063734-49-5)

Safety Data

• Hazardous Substances Data: 1063734-49-5(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-pyrazol-4-aMine dihydrochloride, also known as Mepyramine, is a chemical compound commonly used as an antihistamine to treat symptoms of allergies such as itching, redness, and swelling. It works by blocking the effects of histamine, a substance in the body that causes allergic symptoms. Mepyramine is a white crystalline powder that is soluble in water and ethanol, and it is often administered in the form of a tablet or injection. It is important to note that Mepyramine may cause drowsiness and should be used with caution, especially when driving or operating heavy machinery.

Upstream product

• 3994-50-1 1-methyl-4-nitropyrazole 
• 69843-13-6 1-methyl-4-aminopyrazole 

Downstream Products

• 1001500-53-3 4-isothiocyanato-1-methyl-1H-pyrazole 
• 796845-64-2 tert‐butyl N‐(1‐methyl‐1H‐pyrazol‐4‐yl)carbamate 

Relevant articles and documents

Kilogram-Scale Preparation of an Aminopyrazole Building Block via Copper-Catalyzed Aryl Amidation

We describe a scalable method for preparing an aminopyrazole building block using copper-catalyzed amidation with acetamide as an ammonia surrogate. This procedure provides an alternative to the standard nitration/reduction sequence and avoids energetic intermediates, specialized hydrogenation equipment, and potentially genotoxic impurities that arise from nitro reduction. The chemistry has been successfully scaled to produce >50 kg of the target compound and demonstrate the viability of this alternative route.

U.V. and 15N N.M.R. Integrated Study of the Protonation of Aminoazoles

The behaviour on protonation of a series of 3-, 4-, and 5-aminoisoxazoles has been studied by 15N n.m.r. spectroscopy.The results confirm that the first protonation site in the 3- and 5-amino derivatives is located at the endocyclic nitrogen atom, while in 4-amino derivatives it is at the exocyclic nitrogen.In addition, the protonation of 3-, 4-, and 5-amino substituted 1-methyl- and 1-phenyl-pyrazoles has been investigated by an integrated u.v. and 15N n.m.r. approach.The first protonation site in the 5-amino derivatives is the pyridine-like endocyclic nitrogen, while in the 4-amino derivatives it is the exocyclic nitrogen.The 3-amino series behaves exceptionally because a tautomeric equilibrium is possible between the endocyclic and exocyclic monocations.In sulphuric acid the position of this equilibrium is dependent on H2SO4 concentration.Diprotonation of these derivatives in concentrated sulphuric acid solutions has also been studied.