106376-09-4

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 3-chloro-, methyl ester
• Synonyms: 1-Piperidinecarboxylic acid, 3-chloro-, methyl ester
• CAS NO: 106376-09-4
• Molecular Formula: C7H12ClNO2
• Molecular Weight: 177.63
• Mol File: 106376-09-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 3-chloro-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 3-chloro-, methyl ester(106376-09-4)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 3-chloro-, methyl ester(106376-09-4)

Safety Data

• Hazardous Substances Data: 106376-09-4(Hazardous Substances Data)

Upstream product

• 56475-87-7 3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 1796-27-6 piperidine-1-carboxylic acid methyl ester 
• 106375-80-8 β-chloro-α-hydroxy-N-(methoxycarbonyl)piperidine 

Relevant articles and documents

Electroorganic chemistry. 99. β-Acetoxylation and β-halogenation of N-methoxycarbonyl cyclic amines

Anodic oxidation of N-(methoxycarbonyl)pyrrolidines (n = 1) and -piperidines (n = 2) (A) gave α,β-disubstituted compounds B, in which the α-substituent was an acetoxy, hydroxy, or methoxy group and the β-substituent was an acetoxy group or halogen atom. The α-substituents of B were easily removed by NaBH4 under acidic conditions to give β-substituted compounds C. A reaction mechanism involving the formation of α,β-unsaturated intermediate E followed by anodic oxidation of E or attack of halogen-active species on E has been presented for the anodic α,β-disubstitution.