106391-24-6Relevant academic research and scientific papers
Synthesis of the deuterated thymidine-d9 and deuterated oligonucleotides
Taniguchi, Yosuke,Cao, Xiuming,Sasaki, Shigeki
, (2019/08/27)
The efficient synthesis of the highly-deuterated thymidine-d9 by the glycosylation reaction between a deuterated nucleobase and deuterated sugar is described. It is also incorporated into the oligonucleotides using a DNA synthesizer. Using this
Deuterated HCV NS5b inhibitor nucleotide derivative and application thereof
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Paragraph 0126-0128, (2017/07/19)
The invention provides a deuterated HCV (Hepatitis C Virus) NS5b inhibitor nucleotide derivative or its pharmaceutically acceptable salts, stereoisomers, tautomer inhibitors and its application in preparation of drugs for treatment or prevention of HCV infection. The inhibitor is represented by a general formula I (shown in the description).
METHOD FOR DEUTERATION OR TRITIATION OF HETEROCYCLIC RING
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Page/Page column 16, (2008/06/13)
The present invention relates to a method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to sealed refluxing state in a deuterated solvent in the presence of an activated catalyst selected form a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. In accordance with a method of the present invention, a hydrogen atom belonging to a heterocyclic ring of a compound having a heterocyclic ring can be very efficiently deuterated because temperature of deuteration reaction can be maintained at higher than boiling point of the solvent. Further, a method for deuteration of the present invention can be applied widely to deuteration of various compounds having a heterocyclic ring which are liable to decomposition under supercritical conditions or acidic conditions, leading to industrial and efficient deuteration of a compound having a heterocyclic ring.
