106391-88-2

Basic information

• Product Name: TERT-BUTYL [(1R)-1-FORMYL-2-METHYLPROPYL]CARBAMATE
• Synonyms: TERT-BUTYL [(1R)-1-FORMYL-2-METHYLPROPYL]CARBAMATE;(R)-tert-butyl 3-methyl-1-oxobutan-2-ylcarbamate;N-BOC-2(R)-2-AMINO-3-METHYL-BUTANAL;TERT-BUTYL (R)-(3-METHYL-1-OXOBUTAN-2-YL)CARBAMATE
• CAS NO: 106391-88-2
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.26
• Mol File: 106391-88-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 278.2±23.0 °C(Predicted)
• Appearance: /
• Density: 0.986±0.06 g/cm3(Predicted)
• PKA: 11.34±0.46(Predicted)
• CAS DataBase Reference: TERT-BUTYL [(1R)-1-FORMYL-2-METHYLPROPYL]CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL [(1R)-1-FORMYL-2-METHYLPROPYL]CARBAMATE(106391-88-2)
• EPA Substance Registry System: TERT-BUTYL [(1R)-1-FORMYL-2-METHYLPROPYL]CARBAMATE(106391-88-2)

Safety Data

• Hazardous Substances Data: 106391-88-2(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL[(1R)-1-FORMYL-2-METHYLPROPYL]CARBAMATE, also known as N-tert-butyl-(1R)-1-formyl-2-methylpropyl carbamate is a chemical compound used in the pharmaceutical industry as a reagent and intermediate in the synthesis of various pharmaceutical products. It belongs to the class of organic compounds known as carbamates, which are a group of compounds containing the functional group RnOC(=O)NR'2. This chemical compound is synthesized by reacting tert-butyl isocyanate with (1R)-1-formyl-2-methylpropylamine. TERT-BUTYL [(1R)-1-FORMYL-2-METHYLPROPYL]CARBAMATE is used in the production of certain drugs and pharmaceuticals, and it may also have other industrial applications. It is important to handle this compound with care, as it is considered toxic and may cause irritation upon contact with skin or eyes.

Upstream product

• 4276-09-9 (R)-2-amino-3-methylbutanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 22838-58-0 Boc-D-Val-OH 
• 190260-92-5 (R)-tert-butyl (1-(methoxy(methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 
• 79069-14-0 (S)-2-<(tert-butoxycarbonyl)amino>-3-methylbutan-1-ol 
• 79069-14-0 tert-butyl [(1R)-1-(hydroxymethyl)-2-methylpropyl]carbamate 
• 106391-85-9 (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate 

Downstream Products

• 1215172-30-7 (S)-1-((R)-2-amino-3-methylbutanoyl)-N-(3-chlorobenzyl)pyrrolidine-2-carboxamide hydrochloride 
• 213315-70-9 tert-butyl [(1R)-1-isopropylprop-2-yn-1-yl]carbamate 
• 1401163-66-3 (3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methyl)amino]-4-methylpentan-2-ol 
• 1401163-69-6 (3R)-3-[({3-fluoro-6-[4-(trifluoromethyl)phenyl]pyridin-2-yl}methylene)amino]-4-methylpentan-2-ol 
• 1075206-62-0 (2S,6R,9S,12R,13S)-13-(tert-butyldimethylsiloxy)-12-isopropyl-6-methyl-2-[(E)-4-(tritylthio)but-1-enyl]-9-(tritylthiomethyl)-1-oxa-5,8,11-triazacyclopentadecane-4,7,10,15-tetraone 
• 1075206-50-6 (7S,11R,14S,17R,18S,E)-18-(tert-butyldimethylsilyloxy)-7-hydroxy-17-isopropyl-11-methyl-9,12,15-trioxo-1,1,1-triphenyl-14-tritylthiomethyl-2-thia-10,13,16-triazaicos-5-en-20-oic acid 
• 1075206-60-8 (3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-hydroxy-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-5-methylhexanoate 
• 1075206-59-5 (3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]propionylamino]-3-tritylthio(propionylamino)}-5-methylhexanoate 
• 1075206-51-7 (3S,4R)-allyl 4-[(S)-2-amino-3-(tritylthio)propanamido]-3-(tert-butyldimethylsiloxy)-5-methylhexanoate 
• 1075206-57-3 (3S,4R)-allyl 4-[(S)-2-(tert-butoxycarbonylamino)-3-(tritylthio)propanamido]-3-(tert-butyldimethylsiloxy)-5-methylhexanoate 
• 1040732-16-8 C₁₃H₁₅NO₃ 
• 1040732-15-7 C₂₃H₃₄N₂O₆ 

Relevant articles and documents

Synthesis of Chiral N-Protected α-Amino Aldehydes by Reduction of N-Protected N-Carboxyanhydrides (UNCAs)

A facile one step synthesis of a wide variety of N-protected (Boc, Z, Fmoc) α-amino aldehydes under mild conditions is described.Pure N-protected (Boc, Z, Fmoc) α-amino aldehydes were obtained in high yields by reduction of N-protected (Z, Boc, Fmoc)-N-ca

Phosphatase Binding Compounds and Methods of Using Same

The present invention provides bifunctional compounds that efficiently dephosphorylate certain phospho-activated target proteins. Such target proteins can be any protein involved in the pathway of a disease or disorder, such as but not limited to cancer, neurodegeneration, metabolic disease, diabetes, insulin resistance, and so forth.

Conformational properties of ascydiacyclamide analogues with cyclic α-amino acids instead of oxazoline residues

Ascidiacyclamide [ASC, cyclo(-Ile-oxazoline-D-Val-thiazole-)2] is a cyclic octapeptide isolated from tunicates. We designed ASC analogues [cyclo(-Ile-Xxx-D-Val-thiazole-)2] in which Pro or a homologue was substituted for oxazoline: [Pro]ASC (Xxx: proline), [Aze]ASC (Xxx: (S)-Azetidine-2-carboxylic acid), [Pip]ASC (Xxx: (S)-Piperidine-2-carboxylic acid) and [ΔPro]ASC (Xxx: (S)-3-pyrroline-2-carboxylic acid) to explore their potential to serve as substitutes for the oxazoline ring. The conformations of these analogues were examined using X-ray diffraction, 1H NMR and CD spectroscopy. In both the crystal and solution states, the conformations of [Pro]ASC, [Aze]ASC and [ΔPro]ASC were novel square structures having two trans imide bonds and stabilized by two intramolecular hydrogen bonds. The crystal structure of [Pip]ASC was a folded conformation with cis and trans imide bonds. Three isomers (cc, ct and tt) were present in a solution of [Pip]ASC. From crystal structures, the degree of puckering in the side chains of Pro and its homologues was estimated to be in the order Pip > Pro > Aze > ΔPro. [Pro]ASC and [Pip]ASC showed strong cytotoxicity, but [Aze]ASC and [ΔPro]ASC showed no cytotoxicity. Among the four analogues, there is consistency between the prolyl ring puckering and cytotoxicity, but not between the peptide backbone structure and cytotoxicity.