1064000-89-0

Basic information

• Product Name: 1-chloro-4-(2,2-dibromo-1-methylcyclopropyl)benzene
• Synonyms: 1-chloro-4-(2,2-dibromo-1-methylcyclopropyl)benzene
• CAS NO: 1064000-89-0
• Molecular Weight: 324.442
• Mol File: 1064000-89-0.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1-chloro-4-(2,2-dibromo-1-methylcyclopropyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-4-(2,2-dibromo-1-methylcyclopropyl)benzene(1064000-89-0)
• EPA Substance Registry System: 1-chloro-4-(2,2-dibromo-1-methylcyclopropyl)benzene(1064000-89-0)

Safety Data

• Hazardous Substances Data: 1064000-89-0(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 75-25-2 Bromoform 
• 1712-70-5 1-chloro-4-(1-methylethenyl)-benzene 

Downstream Products

• 1592-34-3 2,3-diethoxybutane 
• 1037048-15-9 1-(buta-2,3-dien-2-yl)-4-chlorobenzene 
• 1064001-44-0 1-chloro-4-(1-methyl-2-cyclopropen-1-yl)benzene 
• 34815-67-3 (Z)-1-(but-2-en-2-yl)-4-chlorobenzene 

Relevant articles and documents

Asymmetric Copper-Catalyzed Carbozincation of Cyclopropenes en Route to the Formation of Diastereo- and Enantiomerically Enriched Polysubstituted Cyclopropanes

The enantioselective synthesis of cyclopropylzinc reagents has been achieved via a copper-catalyzed carbozincation of 3,3-disubstituted cyclopropenes with diorganozinc reagents. The obtained organozinc compounds can be easily functionalized with a broad range of electrophiles, including palladium-catalyzed cross-couplings, affording highly substituted cyclopropanes. The operationally simple procedure using very low quantities of a commercially available and inexpensive copper catalyst provides a new tool for the synthesis of highly enantioenriched cyclopropanes as single diastereoisomers.

Rhodium-Catalyzed Intermolecular Cyclopropanation of Benzofurans, Indoles, and Alkenes via Cyclopropene Ring Opening

The generation of metal carbenoids via ring opening of cyclopropenes by transition metals offers a simple entry into highly reactive intermediates. Herein, we describe a diastereoselective intermolecular rhodium-catalyzed cyclopropanation of heterocycles and alkenes using cyclopropenes as carbene precursors with a low loading of a commercially available rhodium catalyst. The reported method is scalable and could be performed with catalyst loadings as low as 0.2 mol %, with no impact to the reaction yield or selectivity.

Stereoselective Synthesis of Vinylcyclopropa[ b]indolines via a Rh-Migration Strategy

A mild rhodium catalytic system has been developed to synthesize vinylcyclopropa[b]indolines through cyclopropanation of indoles with vinyl carbenoids generated from ring opening of cyclopropenes in situ. By employing a Rh-migration strategy, the products can be obtained with good to excellent E:Z ratios (≤99:1) and complete diastereoselectivity (≤99:1). This method is easy, has a low catalyst loading, and works for a broad range of functionalities.