1064139-43-0

Basic information

• Product Name: tert-butyl 3-[(1-benzyl-1H-indol-5-yl)methyl]-1,2-diazaspiro[4,5]decane-2-carboxylate
• Synonyms: tert-butyl 3-[(1-benzyl-1H-indol-5-yl)methyl]-1,2-diazaspiro[4,5]decane-2-carboxylate
• CAS NO: 1064139-43-0
• Molecular Weight: 459.632
• Mol File: 1064139-43-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-[(1-benzyl-1H-indol-5-yl)methyl]-1,2-diazaspiro[4,5]decane-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-[(1-benzyl-1H-indol-5-yl)methyl]-1,2-diazaspiro[4,5]decane-2-carboxylate(1064139-43-0)
• EPA Substance Registry System: tert-butyl 3-[(1-benzyl-1H-indol-5-yl)methyl]-1,2-diazaspiro[4,5]decane-2-carboxylate(1064139-43-0)

Safety Data

• Hazardous Substances Data: 1064139-43-0(Hazardous Substances Data)

Upstream product

• 10075-51-1 1-benzyl-5-bromo-1H-indole 
• 1064138-80-2 tert-butyl 2-(1-allylcyclohexyl)hydrazinecarboxylate 

Relevant articles and documents

Stereoselective synthesis of cis- or trans-3,5-disubstituted pyrazolidines via pd-catalyzed carboamination reactions: Use of allylic strain to control product stereochemistry through N-substituent manipulation

The stereoselective synthesis of either trans- or cis-3,5-disubstituted pyrazolidines is accomplished via Pd-catalyzed carboamination reactions of unsaturated hydrazine derivatives. The products are obtained in good yield with up to >20:1 diastereoselectivity. Stereocontrol is achieved by modulating the degree of allylic strain in the transition state for syn-aminopalladation through a simple modification of the substrate N2-substituent. The pyrazolidine products can be further transformed to 3,5-disubstituted pyrazolines via deprotection/oxidation, or to substituted 1,3-diamines via N-N bond cleavage.