1064188-13-1

Basic information

• Product Name: C₁₂H₁₉OP
• Synonyms: C₁₂H₁₉OP
• CAS NO: 1064188-13-1
• Molecular Weight: 210.256
• Mol File: 1064188-13-1.mol

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₉OP(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₉OP(1064188-13-1)
• EPA Substance Registry System: C₁₂H₁₉OP(1064188-13-1)

Safety Data

• Hazardous Substances Data: 1064188-13-1(Hazardous Substances Data)

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
• 25979-07-1 tert-butyldichlorophosphine 

Relevant articles and documents

Palladium-phosphinous acid-catalyzed cross-coupling of aryl and acyl halides with aryl-, alkyl-, and vinylzinc reagents

(Chemical Equation Presented) Several palladium-phosphinous acids have been prepared and employed in cross-coupling reactions of aryl or acyl halides with aliphatic and aromatic organozinc reagents. The POPd7-catalyzed reaction of aryl halides, including electron-rich aryl chlorides, and arylzinc reagents was found to afford biaryls exhibiting alkoxy, alkylthio, amino, ketone, cyano, nitro, ester, and heteroaryl groups in 75-93% yield. Excellent results were obtained with sterically hindered substrates which gave di- and tri-ortho-substituted biaryls in up to 92% yield. Aryl halides also undergo POPd7-catalyzed aryl-vinyl and aryl-alkyl bond formation under mild conditions. Styrenes and alkylarenes were prepared in 79-93% yield from aryl halides and vinyl or alkylzinc reagents. The replacement of aryl halides by acyl halides provides access to ketones which were produced in up to 98% yield when POPd was used as catalyst. This approach overcomes the limited substrate scope, reduced regiocontrol, and low functional group tolerance of traditional Friedel-Crafts acylation methods.