1064288-24-9 Usage
General Description
(E)-1-(3-hydroxy-4-(MorpholinoMethyl)phenyl)-3-(pyridin-4-yl)prop-2-en-1-one is a chemical compound with a complex molecular structure. It contains a hydroxyl group and a morpholinomethyl group attached to a phenyl ring, as well as a pyridinyl group attached to a propenone moiety. (E)-1-(3-hydroxy-4-(MorpholinoMethyl)phenyl)-3-(pyridin-4-yl)prop-2-en-1-one has potential applications in the field of medicinal chemistry, due to its structural features that may contribute to biological activity. Further research and testing would be necessary to fully understand the properties and potential uses of this chemical compound.
Check Digit Verification of cas no
The CAS Registry Mumber 1064288-24-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,4,2,8 and 8 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1064288-24:
(9*1)+(8*0)+(7*6)+(6*4)+(5*2)+(4*8)+(3*8)+(2*2)+(1*4)=149
149 % 10 = 9
So 1064288-24-9 is a valid CAS Registry Number.
1064288-24-9Relevant articles and documents
Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents
Reddy, M. Vijaya Bhaskar,Su, Chung-Ren,Chiou, Wen-Fei,Liu, Yi-Nan,Chen, Rosemary Yin-Hwa,Bastow, Kenneth F.,Lee, Kuo-Hsiung,Wu, Tian-Shung
, p. 7358 - 7370 (2008/12/22)
The chalcone skeleton (1,3-diphenyl-2-propen-1-one) is a unique template that is associated with various biological activities. We synthesized Mannich bases of heterocyclic chalcones (9-47) using a one-step Claisen-Schmidt condensation of heterocyclic aldehydes with Mannich bases of acetophenones, and tested the target compounds for cytotoxicity against three human cancer cell lines (prostate, PC-3; breast, MCF-7; nasopharynx, KB) and a multi-drug resistant subline (KB-VIN). Out of the 39 chalcones synthesized, 31 compounds showed potent activity against at least one cell line with IC50 values ranging from 0.03 to 3.80 μg/mL. Structure-activity relationships (SAR) are also discussed.
