1064288-27-2

Basic information

• Product Name: C₁₉H₂₁NO₃S
• Synonyms: C₁₉H₂₁NO₃S
• CAS NO: 1064288-27-2
• Molecular Weight: 343.447
• Mol File: 1064288-27-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₁NO₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₁NO₃S(1064288-27-2)
• EPA Substance Registry System: C₁₉H₂₁NO₃S(1064288-27-2)

Safety Data

• Hazardous Substances Data: 1064288-27-2(Hazardous Substances Data)

Upstream product

• 5834-16-2 3-methyl-2-thiophenecarboxaldehdye 
• 1064288-40-9 1-[3-hydroxy-2-(morpholinomethyl)phenyl]ethanone 

Relevant articles and documents

Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents

The chalcone skeleton (1,3-diphenyl-2-propen-1-one) is a unique template that is associated with various biological activities. We synthesized Mannich bases of heterocyclic chalcones (9-47) using a one-step Claisen-Schmidt condensation of heterocyclic aldehydes with Mannich bases of acetophenones, and tested the target compounds for cytotoxicity against three human cancer cell lines (prostate, PC-3; breast, MCF-7; nasopharynx, KB) and a multi-drug resistant subline (KB-VIN). Out of the 39 chalcones synthesized, 31 compounds showed potent activity against at least one cell line with IC50 values ranging from 0.03 to 3.80 μg/mL. Structure-activity relationships (SAR) are also discussed.