106429-52-1

Basic information

• Product Name: 1H-Benzimidazole-5-methanol,2-methyl-(9CI)
• Synonyms: 1H-Benzimidazole-5-methanol,2-methyl-(9CI);2-methyl-1H-Benzimidazole-6-methanol;(2-methyl-1H-benzo[d]imidazol-5-yl)methanol;(2-Methyl-1H-benzoimidazol-5-yl)-methanol;(2-methyl-1H-benzimidazol-5-yl)methanol
• CAS NO: 106429-52-1
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.1885
• Product Categories: BENZIMIDAZOLE
• Mol File: 106429-52-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 442.4±20.0 °C(Predicted)
• Appearance: /
• Density: 1.295±0.06 g/cm3(Predicted)
• PKA: 11.97±0.10(Predicted)
• CAS DataBase Reference: 1H-Benzimidazole-5-methanol,2-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-5-methanol,2-methyl-(9CI)(106429-52-1)
• EPA Substance Registry System: 1H-Benzimidazole-5-methanol,2-methyl-(9CI)(106429-52-1)

Safety Data

• Hazardous Substances Data: 106429-52-1(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole-5-methanol,2-methyl-(9CI) is an organic chemical compound with the molecular formula C9H10N2O. It is a derivative of benzimidazole, which is a heterocyclic aromatic compound. 1H-Benzimidazole-5-methanol,2-methyl-(9CI) is commonly used as a building block in the synthesis of various pharmaceuticals, agricultural chemicals, and other organic compounds. It possesses a methyl group at the second position of the benzimidazole ring, which can affect its chemical and biological properties. The compound has potential applications in medicinal chemistry, particularly in the development of new drugs for the treatment of various diseases. Its structure and properties make it a valuable intermediate for the synthesis of diverse organic molecules in the chemical industry.

Upstream product

• 709-19-3 2-methyl-3H-benzo[d]imidazole-5-carboxylic acid 
• 106429-51-0 methyl 2-methyl-1H-benzo[d]imidazole-6-carboxylate 
• 717-37-3 ethyl 2-methyl-1H-benzimidazole-5-carboxylate 
• 106429-51-0 methyl 2-methylbenzimidazole-5-carboxylate hydrochloride 

Downstream Products

• 267875-44-5 5-(Aminomethyl)-2-methylbenzimidazole 

Relevant articles and documents

OGA INHIBITOR COMPOUNDS

The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C90RF72 mutations.

THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS

Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, ne

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY2or N; d is CY3or N; e is CY4or N; f is CY5or N; g is CY6or N; Y4, Y5, and Y6are independently hydrogen, C1-4alkyl, or halogen; Y1and Y2are independently hydrogen, C1-4alkyl, C3-7cycloalkyl, halogen, NH2, OH or C1-4alkoxy, and Y3is hydrogen, C1-4alkyl, C3-7cycloalkyl, halogen, —CN, NH2, OH or C1-4alkoxy; A is and W, W1, R1, R3, R4, R5, X and Z are defined in the specification.