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Relevant academic research and scientific papers

Ionophore silica-coated magnetite nanoparticles as a recyclable heterogeneous catalyst for one-pot green synthesis of 2,4,5-trisubstituted imidazoles

Novel multi-SO3H functionalized strong Br?nsted acidic ionic liquid coated magnetite nanoparticles have been prepared and applied as catalyst for the synthesis of 2,4,5-trisubstituted imidazoles. The results showed that a novel catalyst was very efficient for the reaction and could be magnetically separated and reused at least 6 times with less reduction in its catalytic activity. Operational simplicity, low cost of the catalyst used, high yields, environmental friendliness, wide applicability, reusability and easy recovery of the catalyst using an external magnet are the most important features of this methodology. The catalyst was characterized by Fourier transform infrared spectroscopy (FT-IR), X-Ray diffraction analysis (XRD), field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray analysis (EDX), dynamic laser scattering (DLS) and vibrating sample magnetometry (VSM).

ZrO2-β-cyclodextrin catalyzed synthesis of 2,4,5-trisubstituted imidazoles and 1,2-disubstituted benzimidazoles under solvent free conditions and evaluation of their antibacterial study

A series of 2,4,5-trisubstituted imidazoles and 1,2-disubstituted benzimidazoles catalyzed by ZrO2-supported-β-cyclodextrin (ZrO2-β-CD) under solvent free conditions have been synthesized and characterized by spectral methods. The nanoparticles (ZrO2-β-CD), prepared by a simple one-pot-coprecipitation method and were characterized by PXRD, SEM, and TEM techniques. The nano (ZrO2-β-CD) particles were found to be an effective heterogeneous reusable catalyst for the effective synthesis of imidazoles and benzimidazoles under solvent free conditions and all of the synthesized derivatives were evaluated for their antibacterial activity against six bacterial strains.

Synthesis and evaluation of 2-(substituted phenyl)-4,5-diphenyl-1H-imidazole derivatives as anticonvulsant agents

Some new 1H-imidazole derivatives were synthesized by carrying out reaction between benzil and substituted benzaldehydes and evaluated for anticonvulsant activity by maximum electroshock seizure model. The synthesized compounds were characterized by infrared, mass,1HNMR, and elemental analysis. The compounds were found to possess significant anticonvulsant effects with 3 bearing bromo substitution being the most active compound among the series.

Fe3O4@SiO2·HM·SO3H as a recyclable heterogeneous nanocatalyst for the microwave-promoted synthesis of 2,4,5-trisubstituted imidazoles under solvent free conditions

A simple, highly versatile and efficient synthesis of 2,4,5-trisubstituted imidazoles is achieved through a three component one pot reaction of benzil, benzaldehyde and NH4OAc. This reaction has been catalyzed by Fe3O4@SiO2·HM·SO3H, a very efficient, novel recyclable heterogeneous catalyst, under microwave irradiation and solvent free conditions. The catalyst can be recovered for the subsequent reactions and reused for at least five rounds, without any appreciable loss of its efficiency.

A convenient method for the preparation of 2,4,5-triaryl imidazoles using barium chloride dispersed on silica gel nanoparticles (BaCl2-nano SiO2) as heterogeneous reusable catalyst

A simple and eco-friendly procedure for the synthesis of 2,4,5-triaryl imidazoles by using Barium chloride dispersed on silica gel nanoparticles (BaCl2-nano SiO2) as heterogeneous reusable catalyst in high yield under thermal conditions has been described.