1064654-96-1Relevant academic research and scientific papers
Organocatalytic sequential α-amination-Horner-Wadsworth-Emmons olefination of aldehydes: Enantioselective synthesis of γ-amino-α, β-unsaturated esters
Kotkar, Shriram P.,Chavan, Vilas B.,Sudalai, Arumugam
, p. 1001 - 1004 (2007)
(Chemical Equation Presented) A novel and highly enantioselective method for the synthesis of γ-amino-α,β-unsaturated esters via tandem α-amination-Horner-Wadsworth-Emmons (HWE) olefination of aldehydes is described. The one-pot assembly has been demonstr
Toward the optimization of continuous-flow aldol and α-amination reactions by means of proline-functionalized silicon packed-bed microreactors
Massi, Alessandro,Cavazzini, Alberto,Zoppo, Luisa Del,Pandoli, Omar,Costa, Valentina,Pasti, Luisa,Giovannini, Pier Paolo
, p. 619 - 622 (2011)
The activity and stability under flow conditions of covalently and non-covalently silica supported proline and proline-like organocatalysts is herein described. The slow aldol reaction of cyclohexanone with p-nitro benzaldehyde and the fast α-amination of
Heterogeneous Dipeptide-Catalyzed α-Amination of Aldehydes in a Continuous-Flow Reactor: Effect of Residence Time on Enantioselectivity
?tv?s, Sndor B.,Szloszr, Aliz,Mndity, Istvn M.,Fül?p, Ferenc
supporting information, p. 3671 - 3680 (2016/01/25)
A solid-supported dipeptide-catalyzed continuous-flow process was developed for the direct enantioselective α-amination of aldehydes with dibenzyl azodicarboxylate as the electrophilic nitrogen source. With residence time control as an efficient tool for
Polymer-immobilized α,α-bis[bis-3,5-(trifluoromethyl)phenyl]prolinol silyl ether: Synthesis and application in the asymmetric α-amination of aldehydes
Guryev, Anton A.,Anokhin, Maksim V.,Averin, Alexei D.,Beletskaya, Irina P.
, p. 410 - 411 (2015/12/30)
α,α-Bis[bis-3,5-(trifluoromethyl)phenyl]prolinol silyl ether anchored onto polystyrene was synthesized and tested in asymmetric α-amination of aldehydes. The catalytic activity and enantioselectivity of the immobilized catalyst persist for 3 cycles.
Proline-catalyzed asymmetric synthesis of syn - And anti -1,3-diamines
Kumar, Pradeep,Jha, Vishwajeet,Gonnade, Rajesh
, p. 11756 - 11764 (2014/01/06)
A general organocatalytic strategy for asymmetric synthesis of both syn/anti-1,3-diamines has been developed. The strategy employs proline-catalyzed sequential α-amination and Horner-Wadsworth-Emmons (HWE) olefination of aldehydes as the key step where sy
Proline-catalysed amination reactions in cyclic carbonate solvents
Beattie, Christopher,North, Michael,Villuendas, Pedro
experimental part, p. 3420 - 3432 (2011/06/22)
Propylene carbonate is shown to be an environmentally friendly and sustainable replacement for dichloromethane and acetonitrile in proline-catalysed α-hydrazinations of aldehydes and ketones. Enantioselectivities comparable to those obtained in convention
Highly efficient and practical pyrrolidine-camphor-derived organocatalysts for the direct α-amination of aldehydes
Liu, Pang-Min,Magar, Dhananjay R.,Chen, Kwunmin
supporting information; scheme or table, p. 5705 - 5713 (2011/01/05)
A series of pyrrolidine-camphor-derived organocatalysts (1-4) were designed and synthesised. These organocatalysts were used for direct α-amination of aldehydes with dialkyl azodicarboxylates to give the desired α-aminated products in high chemical yields
