106467-05-4

Upstream product

• 40546-33-6 3-[imidazol-4⁽⁵⁾-yl]propylamine 
• 112758-46-0 1-Benzoyl-3-[2-(1-methyl-1H-imidazol-2-ylmethylsulfanyl)-ethyl]-2-phenyl-isourea 
• 45895-41-8 2-(1-methyl-1H-imidazol-2-ylmethylsulfanyl)-ethylamine 
• 81282-38-4 N-diphenoxymethylene benzamide 

Relevant academic research and scientific papers

IMIDAZOLYL ALKYL GUANIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS

New imidazolylalkyl-guanidine derivatives are described, which by virtue of their agonistic action on histamine-H 2 receptors and in part also due to their additional H 1-antagonistic receptor activity can be used in the treatment of cardiac diseases, certain forms of hypertension and diseases of arterial occlusion.These imidazolylalkyl-guanidine derivatives correspond to the general formula I: STR1

Synthesis and pharmacological activity of substituted imidazolyl- and thiazolylmethylthioethylguanidines

Starting with diphenyl N-benzoyl-carbonimidate impromidine analogues characterized by various substituted imidazole or thiazole groups instead of the 5-methylimidazole part have been synthesized and tested for H2-agonistic and H1-antagonistic activity as well. The most potent substances 6h,i are 20-30 times more active than histamine at the H1-receptors in the isolated spontaneously beating guinea-pig right atrium. In isolated perfused guinea-pig hearts 6h,i were found to predominantly stimulate heart rate, whereas the increase in LVdp/dt(max) was about 40% of impromidine's maximal response.