106475-47-2

Basic information

• Product Name: ethyl 4-anilino-2-(methylsulfanyl)pyrimidine-5-carboxylate
• Synonyms: ethyl 4-anilino-2-(methylsulfanyl)pyrimidine-5-carboxylate;ethyl 2-(methylthio)-4-(phenylamino)pyrimidine-5-carboxylate
• CAS NO: 106475-47-2
• Molecular Formula: C₁₄H₁₅N₃O₂S
• Molecular Weight: 289.3528
• Mol File: 106475-47-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ethyl 4-anilino-2-(methylsulfanyl)pyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-anilino-2-(methylsulfanyl)pyrimidine-5-carboxylate(106475-47-2)
• EPA Substance Registry System: ethyl 4-anilino-2-(methylsulfanyl)pyrimidine-5-carboxylate(106475-47-2)

Safety Data

• Hazardous Substances Data: 106475-47-2(Hazardous Substances Data)

Upstream product

• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 62-53-3 aniline 
• 53554-29-3 ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate 

Downstream Products

• 500880-36-4 2-(methylthio)-4-(phenylamino)pyrimidine-5-carboxamide 
• 211245-59-9 2-methanesulfinyl-8-phenyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 211245-58-8 2-Methanesulfanyl-8-phenyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 211245-56-6 2-methanesulfanyl-4-phenylamino-pyrimidine-5-carboxaldehyde 
• 211245-55-5 (2-Methanesulfanyl-4-phenylamino-pyrimidin-5-yl)-methanol 
• 1315513-48-4 7-amino-2-methanesulfinyl-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide 
• 1315513-47-3 7-amino-2-methanesulfonyl-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide 
• 1315513-84-8 7-Amino-2-[2-methoxy-4-(2-pyrrolidin-1-ylethyl)phenylamino]-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide 
• 1315513-78-0 7-Amino-2-[2-methoxy-4-(1-methylpiperid-4-yl)phenylamino]-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide 
• 1315513-49-5 tert-Butyl 4-[4-(7-amino-6-carbamoyl-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)-3-methoxyphenyl]piperidine-1-carboxylate 
• 1315513-46-2 7-Amino-2-methylsulfanyl-5-oxo-8-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide 
• 1315513-45-1 2-Methylsulfanyl-4-phenylamino-5-pyrimidinecarboxylic acid fluoride 
• 857200-26-1 2-(methylthio)-4-(phenylamino)pyrimidine-5-carboxylic acid 
• 185040-34-0 (4-ethylamino-2-methanesulfanyl-pyrimidin-5-yl)-methanol 

Relevant articles and documents

Discovery of the c-Jun N-Terminal Kinase Inhibitor CC-90001

As a result of emerging biological data suggesting that within the c-Jun N-terminal kinase (JNK) family, JNK1 and not JNK2 or JNK3 may be primarily responsible for fibrosis pathology, we sought to identify JNK inhibitors with an increased JNK1 bias relative to our previous clinical compound tanzisertib (CC-930). This manuscript reports the synthesis and structure-activity relationship (SAR) studies for a novel series of JNK inhibitors demonstrating an increased JNK1 bias. SAR optimization on a series of 2,4-dialkylamino-pyrimidine-5-carboxamides resulted in the identification of compounds possessing low nanomolar JNK inhibitory potency, overall kinome selectivity, and the ability to inhibit cellular phosphorylation of the direct JNK substrate c-Jun. Optimization of physicochemical properties in this series resulted in compounds that demonstrated excellent systemic exposure following oral dosing, enabling in vivo efficacy studies and the selection of a candidate for clinical development, CC-90001, which is currently in clinical trials (Phase II) in patients with idiopathic pulmonary fibrosis (NCT03142191).

5 OXO-5,8-DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES

The present invention relates to 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives, to their preparation and to their therapeutic use.

Pyridopyrimidinone derivatives for treatment of neurodegenerative disease

This invention provides pyridopyrimidines and 4-aminopyrimidines that are useful for treating cell proliferatives disorders, such as cancer and restenosis. We have now discovered a group of 7,8-dihydro-2 (amino and thio)pyrido[2,3-d]pyrimidines and 2,4-di