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106483-68-5

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106483-68-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 106483-68-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,4,8 and 3 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 106483-68:
(8*1)+(7*0)+(6*6)+(5*4)+(4*8)+(3*3)+(2*6)+(1*8)=125
125 % 10 = 5
So 106483-68-5 is a valid CAS Registry Number.

106483-68-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,5,6,7-tetrabromo-2,2-dihydroxyindene-1,3-dione

1.2 Other means of identification

Product number -
Other names Tetrabromoninhydrin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:106483-68-5 SDS

106483-68-5Downstream Products

106483-68-5Relevant articles and documents

Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion

Bouzina, Abdeslem,Berredjem, Malika,Nocentini, Alessio,Bua, Silvia,Bouaziz, Zouhair,Jose, Joachim,Le Borgne, Marc,Marminon, Christelle,Gratteri, Paola,Supuran, Claudiu T.

, (2020/10/18)

Ninhydrins show extensive application in organic chemistry and agriculture whereas they have been poorly investigated as bioactive molecules for medicinal chemistry purposes. A series of ninhydrin derivatives was here investigated for the inhibition of human carbonic anhydrases (CAs, EC 4.2.1.1), based on earlier evidence that gem diols are able to coordinate the metal ion from the CA active site. Ninhydrins demonstrated a micromolar inhibitory action against CA I and IX (KIs in the range 0.57–68.2 μM) and up to a nanomolar efficacy against CA II and VII (KIs in the range 0.025–78.2 μM), validated isoforms as targets in several CNS-related diseases. CA IV was instead weakly or poorly inhibited. A computational protocol based on docking, MM-GBSA and metadynamics calculations was used to elucidate the putative binding mode of this type of inhibitors to CA II and CA VII. The findings of this study testify that such pharmacologically underestimated ligands may represent interesting lead compounds for the development of CA inhibitors possessing an innovative mechanism of action, i.e., mono- or bis-coordination to the zinc ion through the diol moiety.

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