1065074-15-8 Usage
General Description
4-(2-Fluorophenyl)-1H-1,2,4-triazol-5(4H)-one is a synthetic organic compound that belongs to a class of chemicals known as 1,2,4-triazoles. It features a fluoro-substituted phenyl group attached to the 4th position of 1,2,4-triazolone ring. The presence of fluorine imparts unique properties to this compound as fluorine is the most electronegative element. 4-(2-Fluorophenyl)-1H-1,2,4-triazol-5(4H)-one, like other triazoles, may have potential applications in medicinal chemistry due to the presence of the 1,2,4-triazolone moiety which is a part of the core structure in numerous pharmaceutical drugs. However, specific information about the chemical's uses, toxicity, safety measures and environmental effects are not extensively available and require further research and investigation.
Check Digit Verification of cas no
The CAS Registry Mumber 1065074-15-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,5,0,7 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1065074-15:
(9*1)+(8*0)+(7*6)+(6*5)+(5*0)+(4*7)+(3*4)+(2*1)+(1*5)=128
128 % 10 = 8
So 1065074-15-8 is a valid CAS Registry Number.
1065074-15-8Relevant articles and documents
Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism
Sheng, Chunquan,Che, Xiaoying,Wang, Wenya,Wang, Shengzheng,Cao, Yongbing,Miao, Zhenyuan,Yao, Jianzhong,Zhang, Wannian
experimental part, p. 5276 - 5282 (2011/12/03)
The incidence of life-threatening fungal infections is increasing dramatically. In an attempt to develop novel antifungal agents, our previously synthesized phenoxyalkylpiperazine triazole derivatives were used as lead structures for further optimization. By means of structure-based bioisosterism, triazolone was used as a new bioisostere of oxygen atom. This type of bioisosteric replacement can improve the water solubility without loss of hydrogen-bonding interaction with the target enzyme. A series of triazolone-containing triazoles were rationally designed and synthesized. As compared with fluconazole, several compounds showed higher antifungal activity with broader spectrum, suggesting their potential for further evaluations.
