1065100-83-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxymethyl-7-azaindole is utilized as a key intermediate in the synthesis of a variety of pharmaceuticals and agrochemicals. Its hydroxymethyl group provides a versatile building block for the creation of a wide range of compounds, making it an essential component in the development of new drugs and chemical products.
Used in Research and Development:
In the field of research, 3-Hydroxymethyl-7-azaindole is studied for its potential biological activities. Its unique structure and properties have attracted interest for applications in anti-inflammatory and anticancer research, where it may contribute to the discovery of novel therapeutic agents.
Used in Chemical Synthesis:
Due to its reactive functional groups and structural features, 3-Hydroxymethyl-7-azaindole is employed as a starting material or building block in the synthesis of complex organic molecules. Its presence in various chemical reactions facilitates the creation of new compounds with specific properties for use in different industries.

Upstream product

• 4649-09-6 1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde 
• 271-63-6 7-Azaindole 
• 50-00-0 formaldehyd 

Downstream Products

• 933691-80-6 7-azaindole-3-methanamine 
• 156270-06-3 7-azaindolyl-3-carboxylic acid 

Relevant academic research and scientific papers

Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors

Anaplastic lymphoma kinase (ALK), a member of the receptor tyrosine kinase family, is predominantly expressed in the brain and implicated in neuronal development and cognition. However, the detailed function of ALK in the central nervous system (CNS) is s

Synthesis method of 7-azaindole-3-carboxylic acid

The invention discloses a synthesis method of 7-azaindole-3-carboxylic acid. The synthesis method of the 7-azaindole-3-carboxylic acid comprises the following steps of adding 7-azaindole and water into a reaction kettle, stirring for 20 to 45min, then adding tetramethyl guanidine and zeolite, heating to 50 to 70 DEG C, adding formaldehyde after uniformly stirring and mixing, carrying out microwaveirradiation for 1 to 2h after uniformly stirring, then continuously stirring for reacting for 6 to 8h, filtering, dissolving a precipitate into dichloromethane, filtering again, carrying out vacuum distillation on a filter liquor, and recrystallizing to obtain 7-azaindole-3-methyl alcohol; oxidizing the 7-azaindole-3-methyl alcohol to obtain the 7-azaindole-3-carboxylic acid. The synthesis methodprovided by the invention is simple to operate, mild in conditions, less in byproducts, high in product purity, and higher in product yield.

Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.