106515-88-2 Usage
Indole compounds
A class of compounds commonly found in natural products Indole compounds are a group of organic compounds that include a five-membered aromatic ring with a nitrogen atom.
Biological activities
Wide range of biological activities Indole compounds have been found to exhibit various biological activities, such as anti-inflammatory, anticancer, and antimicrobial properties.
Substituted fluorophenyl group
A fluorine atom attached to a phenyl ring The presence of a fluorine atom on the phenyl ring can influence the compound's reactivity, stability, and interaction with other molecules.
Methyl group
A CH3 group attached to the indole ring The methyl group is an alkyl group that can affect the compound's lipophilicity, stability, and potential biological activity.
Medicinal chemistry and drug development
Potential applications due to structural features and biological functions The compound's unique structure and potential biological activities make it a promising candidate for further research and development in the field of medicinal chemistry and drug discovery.
Pharmacological properties
Various properties such as anti-inflammatory, anticancer, and antimicrobial activities These properties make indole compounds interesting targets for research and development in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 106515-88-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,5,1 and 5 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 106515-88:
(8*1)+(7*0)+(6*6)+(5*5)+(4*1)+(3*5)+(2*8)+(1*8)=112
112 % 10 = 2
So 106515-88-2 is a valid CAS Registry Number.
106515-88-2Relevant academic research and scientific papers
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles
Perregaard,Arnt,Bogeso,Hyttel,Sanchez
, p. 1092 - 1101 (2007/10/02)
A series of 1-(4-fluorophenyl)-1H-indoles substituted at the 3-position with 1-piperazinyl, 1,2,3,6-tetrahydro-4-pyridinyl, and 4-piperidinyl was synthesized. Within all three subseries potent dopamine D-2 and serotonin 5- HT2 receptor affinity was found in ligand binding studies. Quipazine-induced head twitches in rats were inhibited by most derivatives as a measure of central 5-HT2 receptor antagonism. Piperazinyl and tetrahydropyridyl indoles were cataleptogenic, while piperidyl substituted indoles surprisingly were found to be noncataleptogenic or only weakly cataleptogenic. Noncataleptogenic piperidyl derivatives also failed to block dopaminergic- mediated stereotypies, that is methyl phenidate-induced gnawing behavior in mice. These profiles resemble that of the atypical neuroleptic clozapine. 1- Ethyl-2-imidazolidinone was found to be the optimal substituent of the basic nitrogen atom in order to avoid catalepsy. The atypical neuroleptic 1-[2-[4- [5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2- imidazolidinone (sertindole, compound 14c) was selected for further development as a result of these structure/activity studies.
